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《Nature，4月6日，In the eye of the COVID-19 cytokine storm》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-04-07

  • In the eye of the COVID-19 cytokine storm

    Natalie Vaninov

    Nature Reviews Immunology (2020)

    Not all patients with COVID-19 develop the same symptoms, but the immunological determinants of a poor prognosis are unknown. In this preprint article, Yang, Y et al. followed a cohort of 53 clinically moderate and severe patients; they conducted a multiplex screen for 48 cytokines and correlated these results with lab tests, clinical characteristics and viral loads. They found a marked increase of 14 cytokines in patients with COVID-19 compared with healthy controls. Continuously high levels of three of these cytokines (CXCL10, CCL7 and IL-1 receptor antagonist) were associated with increased viral load, loss of lung function, lung injury and a fatal outcome.

  • 原文来源：https://www.nature.com/articles/s41577-020-0305-6
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    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-12-23
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    • 编译者：zhangmin
    • 发布时间：2020-04-12
    • Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy. Harvey B Pollard, Bette S. Pollard, John R. Pollard doi: https://doi.org/10.1101/2020.04.09.034983 Abstract Influenza viruses, corona viruses and related pneumotropic viruses cause sickness and death partly by inducing a hyper-proinflammatory response by immune cells and cytokines in the host airway. Here we show that the cardiac glycoside digitoxin suppresses this response induced by influenza virus strain A/Wuhan/H3N2/359/95 in the cotton rat lung. The cytokines TNFa, GRO/KC, MIP2, MCP1, TGFb, and IFNg. are significantly reduced. Since the hyper-proinflammatory overproduction of cytokines is a host response, we suggest that digitoxin may have therapeutic potential for not only influenza and but also for coronovirus infections. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
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