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《BioRxiv，4月11日，Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy.》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-04-12

  • Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy.

    Harvey B Pollard, Bette S. Pollard, John R. Pollard

    doi: https://doi.org/10.1101/2020.04.09.034983

    Abstract

    Influenza viruses, corona viruses and related pneumotropic viruses cause sickness and death partly by inducing a hyper-proinflammatory response by immune cells and cytokines in the host airway. Here we show that the cardiac glycoside digitoxin suppresses this response induced by influenza virus strain A/Wuhan/H3N2/359/95 in the cotton rat lung. The cytokines TNFa, GRO/KC, MIP2, MCP1, TGFb, and IFNg. are significantly reduced. Since the hyper-proinflammatory overproduction of cytokines is a host response, we suggest that digitoxin may have therapeutic potential for not only influenza and but also for coronovirus infections.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.04.09.034983v1
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