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《Science，12月9日，Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-12-23

  • RESEARCH ARTICLECORONAVIRUS
    Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm
    View ORCID ProfilePhilip A. Mudd1,*,†, View ORCID ProfileJeremy Chase Crawford2,†, View ORCID ProfileJackson S. Turner3, View ORCID ProfileAisha Souquette2, Daniel Reynolds4, View ORCID ProfileD...

    Science Advances  09 Dec 2020:
    Vol. 6, no. 50, eabe3024
    DOI: 10.1126/sciadv.abe3024

    Abstract
    We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface human leukocyte antigen (HLA)–class II expression on selected monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes predicted severe COVID-19 disease. In contrast to prevailing assumptions, very few (7 of 168) patients with COVID-19 exhibited cytokine profiles indicative of cytokine storm syndrome. After controlling for multiple factors including age and sample time point, patients with COVID-19 exhibited lower cytokine levels than patients with influenza. Up-regulation of IL-6, G-CSF, IL-1RA, and MCP1 predicted death in patients with COVID-19 but were not statistically higher than patients with influenza. Single-cell transcriptional profiling revealed profound suppression of interferon signaling among patients with COVID-19. When considered across the spectrum of peripheral immune profiles, patients with COVID-19 are less inflamed than patients with influenza.

  • 原文来源：https://advances.sciencemag.org/content/6/50/eabe3024
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