Molecular mechanism of SARS-Cov-2 components caused ARDS in murine model
View ORCID ProfileTingxuan Gu, Simin Zhao, Guoguo Jin, Mengqiu Song, Yafei Zhi, Ran Zhao, Fayang Ma, Yaqiu Zheng, Keke Wang, Hui Liu, Mingxia Xin, Xiang Li, Christopher D Dong, Kangdong Liu, Zigang Dong
doi: https://doi.org/10.1101/2020.06.07.119032
Abstract
COVID-19 becomes the biggest challenge to global health, and until now, no efficient antiviral agents were developed for the treatment. SARS-Cov-2 infection is characterized by pulmonary and systemic inflammation, multi-organ dysfunctions were observed in severe patients, acute respiratory distress syndrome (ARDS) and respiratory failure contribute to most mortality cases. There is an urgent need for an effective treatment for antiviral agents, vaccines against SARS-Cov-2 and SARS-Cov-2-caused ARDS. However, most research laboratories do not have a biosecurity P3 or P4 laboratory and thus cannot conduct SARS-Cov-2 virus research or SARS-Cov-2 caused ARDS study. Here, we developed a non-infectious, highly safety, SARS-Cov-2 components induced murine model for COVID-19, to study the SARS-Cov-2 caused ARDS and cytokine storm syndrome (CSS). We explored a robustness murine animal model for anti-inflammation treatment of COVID-19 to study the mechanism of ARDS and CSS which caused by SARS-Cov-2. We have test mAbs and inhibitors which potently neutralize the pro-inflammatory phenotype from COVID-19, which find these mAbs or agents can significantly relieve pulmonary and CSS in the lung.
Competing Interest Statement
The authors have declared no competing interest.
