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《Science，7月2日，Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-07-07

  • Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques
    Wei Deng1,*, Linlin Bao1,*, Jiangning Liu1,*, Chong Xiao1,*, Jiayi Liu2,*, Jing Xue1,*, Qi Lv1,*, Feifei Qi1

    See all authors and affiliations

    Science  02 Jul 2020:
    eabc5343
    DOI: 10.1126/science.abc5343

    Abstract
    Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It currently remains unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques.

  • 原文来源：https://science.sciencemag.org/content/early/2020/07/01/science.abc5343
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    • 编译者：zhangmin
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