《Medicalxpress,12月7日,Biomarker discovery makes early detection of high-risk COVID-19 patients possible》

  • 来源专题:COVID-19科研动态监测
  • 编译者: YUTING
  • 发布时间:2021-12-15
  • Researchers have discovered a biomarker that could assist in the early identification of people at high risk of developing severe COVID-19.

    Led by computational researchers from WEHI, in collaboration with The University of Queensland, Queensland University of Technology and Hospital Marcelino Champagnat in Brazil, the study used advanced spatial transcriptomic techniques to screen for genes associated with excessive inflammation in the lungs, a key indicator of severe COVID-19.

    Recently published in the European Respiratory Journal the findings have the potential to revolutionize the way patients are treated and alleviate pressure on the nation's healthcare system.

    The researchers are now participating in an international effort to translate this research into a diagnostic test to identify patients at high-risk of severe COVID-19 during the early stages of their infection, to better target health-care intervention and prevent ICU admissions associated with severe disease.

  • 原文来源:https://medicalxpress.com/news/2021-12-biomarker-discovery-early-high-risk-covid-.html
相关报告
  • 《Nature,12月7日,Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-12-22
    • Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19 Ying X. Gue, Maria Tennyson, Jovia Gao, Shuhui Ren, Rahim Kanji & Diana A. Gorog Scientific Reports volume 10, Article number: 21379 (2020) Abstract Patients hospitalised with COVID-19 have a high mortality. Identification of patients at increased risk of adverse outcome would be important, to allow closer observation and earlier medical intervention for those at risk, and to objectively guide prognosis for friends and family of affected individuals. We conducted a single-centre retrospective cohort study in all-comers with COVID-19 admitted to a large general hospital in the United Kingdom. Clinical characteristics and features on admission, including observations, haematological and biochemical characteristics, were used to develop a score to predict 30-day mortality, using multivariable logistic regression. We identified 316 patients, of whom 46% died within 30-days. We developed a mortality score incorporating age, sex, platelet count, international normalised ratio, and observations on admission including the Glasgow Coma Scale, respiratory rate and blood pressure.
  • 《Medicalxpress,12月13日,Scientists develop an RNA-based breath test to detect COVID-19》

    • 来源专题:COVID-19科研动态监测
    • 编译者:YUTING
    • 发布时间:2021-12-18
    • In a new study in The Journal of Molecular Diagnostics, investigators report on the design and testing of a breathalyzer, known as the Bubbler, that relies on viral RNA detection to diagnose SARS-CoV-2. Its name is derived from the bubbling sound that occurs when the patient exhales into the device. The Bubbler not only reverse transcribes RNA from airborne virus particles into DNA to be tested via PCR but can also barcode that DNA, allowing samples to be linked directly to the patient they have come from and be used for sequencing. It can be used for simultaneous batches of pooled samples and provides additional information such as viral load and strain identity and eliminates the need for stabilizing a sample, potentially allowing the assay to be performed at home. "Involvement of the lower respiratory tract is often a precursor to severe COVID-19, so there is an argument for a more direct sampling focused on exhaled breath," explained lead investigator William G. Fairbrother, Ph.D., professor in the department of molecular biology, cell biology and biochemistry at Brown University in Providence, RI, U.S. Virus detection by the Bubbler is similar to a hospital-swab PCR test; however, it is a better measure of risk of contagion as it detects airborne viral particles. Swab tests can return a positive result for months after infection as they detect viral RNA fragments in cells that persist in previously infected cells. The Bubbler can also be adapted for environmental sampling in hospitals, transportation hubs, and closed environments like offices, ships, and planes, the investigators report. Seventy patients treated in the Emergency Department of Rhode Island Hospital between May 2020 and January 2021 were screened. The study tested samples from three points in the respiratory tract. Tongue scrapes from the mouth (saliva/tongue scrapes) and from 15 seconds of exhaled breath collected in the Bubbler were compared to those from a conventional nasopharyngeal swab PCR test. The Bubbler is a glass tube with a glass pipette through which patients can exhale. The tube is filled with a reverse transcription reaction mixture and cold mineral oil.