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《ChemRxiv，2月13日，Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-02-14

  • Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins

    Preprint submitted on 13.02.2020, 19:45 and posted on 13.02.2020, 13:29 by Alessandro Contini

    The infection by the 2019-nCoV coronavirus (COVID-19) is a world-wide emergency.

    The crystal structure of a protein essential for virus replication has been filed in the Protein Data Bank recently. Additionally, homology models of 24 COVID-19 proteins were made available by the Zhang group. In this paper, we present results deriving from the virtual screening of a database of more than 3000 FDA approved drugs on two distinct targets. Results showed that some of the known protease inhibitors currently used in HIV infections might be helpful for the therapy of COVID-19 also.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://chemrxiv.org/articles/Virtual_Screening_of_an_FDA_Approved_Drugs_Database_on_Two_COVID-19_Coronavirus_Proteins/11847381
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