登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《ChemRxiv，3月19日，Identification of FDA Approved Drugs Targeting COVID-19 Virus by Structure-Based Drug Repositioning》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-23

  • Identification of FDA Approved Drugs Targeting COVID-19 Virus by Structure-Based Drug Repositioning

    Preprint submitted on 19.03.2020, 11:01 and posted on 19.03.2020, 19:14 by Ayman Farag Ping Wang Mahmoud Ahmed Hesham Sadek

    The new strain of Coronaviruses (SARS-CoV-2), and the resulting Covid-19 disease has spread swiftly across the globe after its initial detection in late December 2019 in Wuhan, China, resulting in a pandemic status declaration by WHO within 3 months. Given the heavy toll of this pandemic, researchers are actively testing various strategies including new and repurposed drugs as well as vaccines. In the current brief report, we adopted a repositioning approach using insilico molecular modeling screening using FDA approved drugs with established safety profiles for potential inhibitory effects on Covid-19 virus.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://chemrxiv.org/articles/Identification_of_FDA_Approved_Drugs_Targeting_COVID-19_Virus_by_Structure-Based_Drug_Repositioning/12003930
109浏览量
原文链接
相关报告

  • 《ChemRxiv，2月19日，Potential Inhibitors Against Papain-like Protease of Novel Coronavirus (COVID-19) from FDA Approved Drugs》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-02-20
    • Potential Inhibitors Against Papain-like Protease of Novel Coronavirus (COVID-19) from FDA Approved Drugs Preprint submitted on 17.02.2020, 01:03 and posted on 19.02.2020, 05:54 by Rimanshee Arya Amit Das Vishal Prashar Mukesh Kumar The cases of 2019 novel coronavirus (COVID-19) infection have been continuously increasing ever since its outbreak in China last December. Currently, there are no approved drugs to treat the infection. In this scenario, there is a need to utilize the existing repertoire of FDA approved drugs to treat the disease. The rational selection of these drugs could be made by testing their ability to inhibit any COVID-19 proteins essential for viral life-cycle. We chose one such crucial viral protein, the papain-like protease (PLpro), to screen the FDA approved drugs in silico. The homology model of the protease was built based on the SARS-coronavirus PLpro structure, and the drugs were docked in S3/S4 pockets of the active site of the enzyme. In our docking studies, fifteen FDA approved drugs, including chloroquine and formoterol, bind the target enzyme with significant affinity and good geometry, suggesting their potential to be utilized against the virus. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    95浏览量
    原文链接

  • 《ChemRxiv，2月13日，Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-02-14
    • Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins Preprint submitted on 13.02.2020, 19:45 and posted on 13.02.2020, 13:29 by Alessandro Contini The infection by the 2019-nCoV coronavirus (COVID-19) is a world-wide emergency. The crystal structure of a protein essential for virus replication has been filed in the Protein Data Bank recently. Additionally, homology models of 24 COVID-19 proteins were made available by the Zhang group. In this paper, we present results deriving from the virtual screening of a database of more than 3000 FDA approved drugs on two distinct targets. Results showed that some of the known protease inhibitors currently used in HIV infections might be helpful for the therapy of COVID-19 also. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    72浏览量
    原文链接