Weight-Based Dosing of Pembrolizumab Every 6 Weeks in the Time of COVID-19
Daniel A. Goldstein, MD1,2; Mark J. Ratain, MD3; Leonard B. Saltz, MD4
Author Affiliations Article Information
JAMA Oncol. Published online May 27, 2020. doi:10.1001/jamaoncol.2020.2493
The coronavirus disease 2019 (COVID-19) pandemic has shocked the world and caused a period of both economic and medical catastrophe. Two major challenges face the world of medical oncology. Oncologists need to reconsider all of their clinical practices to decrease the risk of exposure of their patients to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Oncologists also need to consider that the world has changed considerably in economic terms. Now, more than ever, we need to assess whether our recommended therapies will cause financial hardship, on both an individual and a societal level. In this article we propose a solution related to the dosing of pembrolizumab that will maintain therapeutic outcomes, decrease detrimental financial effects of treatment, and decrease exposure risk to SARS-CoV-2.