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《Nature，7月24日，Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-07-28

  • Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

    Laura Riva, Shuofeng Yuan, […]Sumit K. Chanda

    Nature (2020)

    Abstract

    The emergence of the novel SARS coronavirus 2 (SARS-CoV-2) in 2019 has triggered an ongoing global pandemic of severe pneumonia-like disease designated as coronavirus disease 2019 (COVID-19)1. The development of a vaccine is likely to require at least 12-18 months, and the typical timeline for approval of a novel antiviral therapeutic can exceed 10 years. Thus, repurposing of known drugs could significantly accelerate the deployment of novel therapies for COVID-19. Towards this end, we profiled a library of known drugs encompassing approximately 12,000 clinical-stage or FDA-approved small molecules. We report the identification of 100 molecules that inhibit viral replication, including 21 known drugs that exhibit dose response relationships.

  • 原文来源：https://www.nature.com/articles/s41586-020-2577-1
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