《TMID,3月8日,Positive result of Sars-Cov-2 in sputum from a cured patient with COVID-19》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-03-10
  • Positive result of Sars-Cov-2 in sputum from a cured patient with COVID-19

    Ye-MinQu, Hai-YanCong

    Show more

    https://doi.org/10.1016/j.tmaid.2020.101619

    To the Editor

    Since December 2019, an outbreak of the novel coronavirus (SARS-CoV-2) infection has spread rapidly in Wuhan, China [1]1. Over a month since the outbreak, more than 13,000 patients with COVID-19 have be cured and discharged from hospital until now. For the clinical cure criteria in China, twice successive negative results of Sars-Cov-2 nucleic acid detection are the important index, in addition to normal body temperature for 3 days as well as obvious improvement in respiratory symptoms and CT scan [2]. In the present work, we reported that Sars-Cov-2 nucleic acid was still detectable in sputum obtained by nebulization from a cured patient.

  • 原文来源:https://www.sciencedirect.com/science/article/pii/S1477893920300879
相关报告
  • 《Current Biology,3月19日,Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-20
    • Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak TaoZhang12QunfuWu12ZhigangZhang13 Show more https://doi.org/10.1016/j.cub.2020.03.022 Summary An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. Therefore, we reinvestigated published data from pangolin lung samples from which SARS-CoV-like CoVs were detected by Liu et al. [1]. We found genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-CoV) in dead Malayan pangolins. Pangolin-CoV is 91.02% and 90.55% identical to SARS-CoV-2 and BatCoV RaTG13, respectively, at the whole-genome level. Aside from RaTG13, Pangolin-CoV is the most closely related CoV to SARS-CoV-2.
  • 《3月8日_已治愈COVID-19患者的痰中检测出Sars-Cov-2阳性结果》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-10
    • 1.时间:2020年3月8日 2.机构或团队:威海市立医院 3.事件概要: 威海市立医院的科研人员在《Travel Medicine and Infectious Disease》上发表论文“Positive result of Sars-Cov-2 in sputum from a cured patient with COVID-19”,介绍了已治愈COVID-19患者(咽拭子检测结果为阴性)的痰中仍能检测出Sars-Cov-2阳性结果的情况。 文章指出,疫情爆发以来一个多月,到目前为止,已有13,000多名COVID-19病人治愈并出院。对于中国的临床治愈标准,除了正常体温3天以及呼吸道症状和CT扫描有明显改善外,Sars-Cov-2核酸检测连续两次阴性结果是重要的指标。在目前的工作中,科研人员报道了从治愈患者中雾化获得的痰中仍可检测到Sars-Cov-2核酸。 1月22日,一名49岁发烧4天的男子到医院检查,实时RT-PCR检测出咽拭子SARS-CoV-2核酸呈阳性。随后,根据诊断标准:(1)SARS-CoV-2核酸检测阳性结果,(2)有14天在武汉短暂停留的历史,(3)发烧症状,以及CT扫描显示的多处斑玻璃混浊区域,诊断患者为COVID-19。积极治疗后,患者于2月4日退烧且恢复其他呼吸道症状,2月9日和2月10日,SARS-CoV-2核酸检测在他的咽拭子样本中连续呈阴性,CT扫描结果表明,两个肺部的炎症均明显减轻。SARS-CoV-2核酸检测结果和CT扫描均表明有恢复趋势,患者已准备出院。2月13日,患者出院前通过雾化收集了咽拭子和痰液。值得注意的是,尽管咽拭子检测结果为阴性,但患者痰液中仍检测到SARS-CoV-2核酸呈阳性。 世卫组织建议,应该对上下呼吸道的两个标本进行测试,以确认SARS-CoV-2的消除,另外科研人员还发现,尽管咽拭子检测结果为阴性,但在下呼吸道标本中仍可能检测到SARS-CoV-2核酸。作者认为,在COVID-19患者可以出院之前,必须收集上下呼吸道的两个标本进行SARS-CoV-2核酸检测。 4.附件: 原文链接: https://www.sciencedirect.com/science/article/pii/S1477893920300879