A simple magnetic nanoparticles-based viral RNA extraction method for efficient detection of SARS-CoV-2
Zhen Zhao, Haodong Cui, Wenxing Song, Xiaoling Ru, Wenhua Zhou, Xuefeng Yu
doi: https://doi.org/10.1101/2020.02.22.961268
Abstract
The ongoing outbreak of the novel coronavirus disease 2019 (COVID-19) originating from Wuhan, China, draws worldwide concerns due to its long incubation period and strong infectivity. Although RT-PCR-based molecular diagnosis techniques are being widely applied for clinical diagnosis currently, timely and accurate diagnosis are still limited due to labour intensive and time-consuming operations of these techniques. To address the issue, herein we report the synthesis of poly (amino ester) with carboxyl groups (PC)-coated magnetic nanoparticles (pcMNPs), and the development of pcMNPs-based viral RNA extraction method for the sensitive detection of COVID-19 causing virus, the SARS-CoV-2.
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