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《Nature，5月5日，Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-05-06

  • Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

    Dongze Li, You Chen, Hong Liu, Yu Jia, Fanghui Li, Wei Wang, Jiang Wu, Zhi Wan, Yu Cao & Rui Zeng

    Signal Transduction and Targeted Therapy volume 5, Article number: 62 (2020)

    A series of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since the end of 2019 is ongoing and triggering a global public health crisis. The estimated case fatality rate is approximately 3.4% in China. However, some patients experience dyspnea within 1 week and develop rapidly to organ injury and even death within 2 weeks after dyspnea.1 In addition, early organ injury could lead to higher risks of mortality. Thus, early identification of patients at risk of organ injury and death is crucial, which saves the patients from classified and invasive treatment, improving clinical outcome and prognosis. The human immune system plays significant roles in the resistance of foreign pathogens and the progress of pneumonia.

  • 原文来源：https://www.nature.com/articles/s41392-020-0163-5
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    • 编译者：xuwenwhlib
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  • 《5月5日_中国COVID-19患者的免疫功能障碍导致死亡和器官损伤》
    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-05-06
    • 信息名称：中国COVID-19患者的免疫功能障碍导致死亡和器官损伤 1.时间：2020年5月5日 2.机构或团队：四川大学华西医院、新疆医科大学第一附属医院 3.事件概要： 四川大学华西医院联合多家机构在Nature子刊Signal Transduction and Targeted Therapy volume发表论文“Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study”。 2020年1月31日至2月18日，文章收纳了509名患者，纳入标准为年龄>18岁，首次诊断为COVID-19，排除治疗前检查无免疫相关指标、妊娠、服用免疫抑制药物或皮质激素、有慢性器官功能障碍或免疫性疾病史、3个月内有手术史、同时有其他疾病感染史，最后，本研究共纳入163例患者。文章基于多中心回顾队列研究分析了来自新型冠状病毒肺炎早期风险分层（ERS-COVID-19）研究的据。主要终点为全因死亡，次要终点为多器官功能障碍综合征和重症肺炎。所有患者入院后随访30天。研究发现COVID-19肺炎表现为免疫功能障碍，即使在轻度肺炎患者中也是如此。患者的白细胞、中性粒细胞、淋巴细胞计数、CD3+、CD4+和CD8+T细胞计数、C4、Hs-CRP和降钙素原对院内死亡率、器官损伤和严重肺炎有很强的预测价值。淋巴细胞亚群减少和中性粒细胞增多，C4和Hs-CRP分别与高死亡率和器官损伤风险独立相关。因此，明确COVID-19肺炎的免疫表型可能有助于特异性免疫治疗的发展，从而避免导致患者预后不良的免疫改变出现。 4.附件： 原文链接：https://www.nature.com/articles/s41392-020-0163-5
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