《JFMA,3月2日,SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-03-03
  • SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics

    QingCao, Yi-ChingChen, Chyi-LiangChen, Cheng-HsunChiu

    Show more

    https://doi.org/10.1016/j.jfma.2020.02.009

    The emergence and spread of a novel coronavirus (SARS-CoV-2) from Wuhan, China, have become a Public Health Emergency of International Concern, designated by World Health Organization. As of February 26, 2020, the National Health Commission of the People's Republic of China has received a total of 77,663 confirmed cases from across China.1 As of February 26, 126 confirmed cases were reported from Hong Kong (HK), Macao, and Taiwan, and 1804 from 37 countries worldwide. During the previous outbreaks of Severe Acute Respiratory Syndrome (SARS) in HK and Middle East Respiratory Syndrome (MERS) in South Korean, very few pediatric patients were reported, respectively. Despite a high mortality rate of SARS and MERS in the adults, there were no fatalities in the pediatric patients. Children appeared to have a milder form of the disease caused by the coronaviruses, including SARS-CoV-2.

  • 原文来源:https://www.sciencedirect.com/science/article/pii/S092966462030067X
相关报告
  • 《NEJM,3月18日,SARS-CoV-2 Infection in Children》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-19
    • TO THE EDITOR: As of March 10, 2020, the 2019 novel coronavirus (SARS-CoV-2) has been responsible for more than 110,000 infections and 4000 deaths worldwide, but data regarding the epidemiologic characteristics and clinical features of infected children are limited.1-3 A recent review of 72,314 cases by the Chinese Center for Disease Control and Prevention showed that less than 1% of the cases were in children younger than 10 years of age.2 In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Children’s Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan.
  • 《Nature,3月13日,Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-14
    • Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding Yi Xu, Xufang Li, Bing Zhu, Huiying Liang, Chunxiao Fang, Yu Gong, Qiaozhi Guo, Xin Sun, Danyang Zhao, Jun Shen, Huayan Zhang, Hongsheng Liu, Huimin Xia, Jinling Tang, Kang Zhang & Sitang Gong Nature Medicine (2020) Abstract We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal–oral transmission.