Understanding COVID-19: what does viral RNA load really mean?
Gavin M Joynt
William KK Wu
Published:March 27, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30237-1
In The Lancet Infectious Diseases, Francois-Xavier Lescure and colleagues1 describe the first cases of coronavirus disease 2019 (COVID-19) in Europe, which were reported in France. The detailed clinical features of five patients with COVID-19 are aligned with the quantitative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA load from nasopharyngeal and other selected sampling sites. Previous studies in patients with SARS, Middle East respiratory syndrome (MERS), and COVID-19 generally provide insufficient detail to allow examination of the relationship between individual patient clinical course and viral RNA load.