《LANCET,3月19日,Viral dynamics in mild and severe cases of COVID-19》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-03-20
  • Viral dynamics in mild and severe cases of COVID-19

    Yang Liu, Li-Meng Yan, Lagen Wan, Tian-Xin Xiang, Aiping Le, Jia-Ming Liu, et al.

    Published:March 19, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30232-2

    Coronavirus disease 2019 (COVID-19) is a new pandemic disease. We previously reported that the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peaks within the first week of disease onset.1, 2 Findings from Feb, 2020, indicated that the clinical spectrum of this disease can be very heterogeneous.3 Here, we report the viral RNA shedding patterns observed in patients with mild and severe COVID-19.

  • 原文来源:https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30232-2/fulltext
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    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-28
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  • 《3月19日_轻度和重症COVID-19病例的病毒动力学》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-03-21
    • 3月19日_轻度和重症COVID-19病例的病毒动力学 1.时间:2020年3月19日 2.机构或团队:南昌大学第一附属医院、香港大学 3.事件概要: 南昌大学第一附属医院多个科室与香港大学公共卫生学院的科研人员在The Lancet Infectious Diseases期刊在线发表题为“Viral dynamics in mild and severe cases of COVID-19”的通讯文章。 研究人员将2020年1月21日至2月4日在南昌大学第一附属医院收治的76例COVID-19确诊患者作为研究对象。所有患者入院时经RT-PCR检测,用DCt方法(Ctsample - Ctref)估计其鼻咽拭子样本的病毒载量。在入院时或入院后具有以下任何特征的患者,被归为重症病例:(1)呼吸窘迫(每分钟≥30次呼吸);(2)静止时血氧饱和度≤93%;(3)动脉血氧分压与吸氧空气分数浓度之比≤300mm Hg;(4)严重的疾病并发症(如呼吸衰竭、需要机械通气、感染性休克或非呼吸器官衰竭)。46例(61%)被归为轻度病例,30例(39%)被归为重症病例。除了重症组的患者明显比轻度组的患者年龄更大之外,两组之间的参数没有显着差异,没有患者死于感染。30例重症患者中有23例(77%)接受了ICU治疗,而轻度病例中无一例需要ICU治疗。 文章还提到,入院时重症病例的DCt值明显低于轻度病例的DCt值。重症病例的平均病毒载量是轻度病例的60倍左右,这表明较高的病毒载量可能与严重的临床结果有关。在发病后的12天内,重症病例的DCt值仍显著低于相应轻度病例的DCt值。轻度病例具有早期病毒清除,其中90%的轻度病例在发病后第10天重复检测RT-PCR,结果为阴性。相比之下,所有重症病例在发病后第10天或以后仍呈阳性。总体而言,COVID-19的重症患者往往具有较高的病毒载量和较长的病毒脱落期,表明SARS-CoV-2的病毒载量可能是评估疾病严重程度和预后的有用标志。 4.附件: 原文链接: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30232-2/fulltext