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《bioRxiv，5月31日，Sofosbuvir protects human brain organoids against SARS-CoV-2》

  • 来源专题：COVID-19科研动态监测
  • 编译者： xuwenwhlib
  • 发布时间：2020-06-02

  • Sofosbuvir protects human brain organoids against SARS-CoV-2

    View ORCID ProfilePinar Mesci, Angela Macia, Aurian Saleh, Laura Martin-Sancho, View ORCID ProfileXIN YIN, Cedric Snethlage, Simoni Avansini, Sumit Chanda, View ORCID ProfileAlysson Muotri

    doi: https://doi.org/10.1101/2020.05.30.125856

    Abstract

    COVID-19 was rapidly declared a pandemic by the World Health Organization, only three months after the initial outbreak in Wuhan, China. Early clinical care mainly focused on respiratory illnesses. However, a variety of neurological manifestations in both adults and newborns are also emerging. To determine whether SARS-CoV-2 could target the human brain, we infected iPSC-derived human brain organoids. Our findings show that SARS-CoV-2 was able to infect and kill neural cells, including cortical neurons. This phenotype was accompanied by impaired synaptogenesis. Finally, Sofosbuvir, an FDA-approved antiviral drug, was able to rescue these alterations. Given that there are currently no vaccine or antiviral treatments available, urgent therapies are needed. Our findings put Sofosbuvir forward as potential treatments to alleviate COVID-19-related neurological symptoms.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.05.30.125856v1
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