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《LANCET，2月12日，What are the risks of COVID-19 infection in pregnant women?》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-02-13

  • What are the risks of COVID-19 infection in pregnant women?

    Jie Qiao

    Published:February 12, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30365-2

    Since December, 2019, the outbreak of the 2019 novel coronavirus disease (COVID-19) infection has become a major epidemic threat in China. As of Feb 11, 2020, the cumulative number of confirmed cases in mainland China has reached 38 800, with 4740 (12·2%) cured cases and 1113 (2·9%) deaths; additionally, there have been 16 067 suspected cases so far.1 All 31 provinces in mainland China have now adopted the first-level response to major public health emergencies. The National Health Commission of China has published a series of guidelines on the prevention, diagnosis, and treatment of COVID-19 pneumonia, based on growing evidence of the pathogens responsible for COVID-19 infection, as well as the epidemiological characteristics, clinical features, and the most effective treatments.2, 3, 4 The central government and some provincial governments have provided food and medical supplies and dispatched expert groups and medical teams to manage and control the outbreak response in the hardest-hit areas (Wuhan and neighbouring cities in Hubei province).

  • 原文来源：https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30365-2/fulltext
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  • 《LANCET，3月17日，COVID-19 in pregnant women – Authors' reply》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-18
    • COVID-19 in pregnant women – Authors' reply David Baud Eric Giannoni Léo Pomar Xiaolong Qi Karin Nielsen-Saines Didier Musso et al. Show all authors Published:March 17, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30192-4 We are grateful for the concerns of Manuel Schmidt and colleagues about our previous guidelines1 for pregnant women with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. At the time we developed the algorithm (February, 2020), there were no data regarding potential vertical transmission from infected mothers and outcomes in newborns. To date, there has been no evidence of vertical transmission of coronavirus disease 2019 (COVID-19) based on two small clinical series.2, 3 According to WHO, delayed umbilical cord clamping is highly unlikely to increase the risk of transmitting pathogens from the mother to the fetus even in the case of maternal infection.4 Because the vernix caseosa contains antimicrobial peptides, we recommend leaving it in place until 24 h after birth.5 New data examining neonates from infected mothers could be reassuring, but transmission after birth via contact with infectious respiratory secretions is still a concern, and physical separation of mother from child should be considered. Separation is a standard practice in pulmonary tuberculosis and is discussed in cases of maternal influenza infection.6 Therefore, separation of the mother and her newborn baby should be individually discussed by an interdisciplinary team, considering local facilities and risk factors for adverse neonatal outcomes, such as prematurity and fetal distress.
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  • 《LANCET，2月12日，Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-02-13
    • Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Huijun Chen, PhD * Juanjuan Guo, MS * Chen Wang, PhD * Fan Luo, PhD Xuechen Yu, MD Prof Wei Zhang, PhD et al. Published:February 12, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30360-3 Summary Background Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. Methods Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. Breastmilk samples were also collected and tested from patients after the first lactation.
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