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《Science，1月8日，Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2021-02-05

  • Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK

    View ORCID ProfileLouis du Plessis1,*, View ORCID ProfileJohn T. McCrone2,*, View ORCID ProfileAlexander E. Zarebski1,*, View ORCID ProfileVerity Hill2,*, View ORCID ProfileChristopher Ruis,...

    Science 08 Jan 2021:

    eabf2946

    DOI: 10.1126/science.abf2946

    Abstract

    The UK’s COVID-19 epidemic during early 2020 was one of world’s largest and unusually well represented by virus genomic sampling. Here we reveal the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 SARS-CoV-2 genomes, including 26,181 from the UK sampled throughout the country’s first wave of infection. Using large-scale phylogenetic analyses, combined with epidemiological and travel data, we quantify the size, spatio-temporal origins and persistence of genetically-distinct UK transmission lineages. Rapid fluctuations in virus importation rates resulted in >1000 lineages; those introduced prior to national lockdown tended to be larger and more dispersed. Lineage importation and regional lineage diversity declined after lockdown, while lineage elimination was size-dependent. We discuss the implications of our genetic perspective on transmission dynamics for COVID-19 epidemiology and control.

  • 原文来源：https://science.sciencemag.org/content/early/2021/01/07/science.abf2946
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