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《Science，6月8日，Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California》

  • 来源专题：COVID-19科研动态监测
  • 编译者： xuwenwhlib
  • 发布时间：2020-06-09

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    Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California

    Eva W. Cheung, MD1; Philip Zachariah, MD, MS1; Mark Gorelik, MD

    Science 08 Jun 2020:

    eabb9263

    DOI: 10.1126/science.abb9263

    Abstract

    The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, with >52,000 cases in California as of May 4, 2020. Here we investigate the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning 9 counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least 7 different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington State, with lack of a predominant lineage and limited transmission between communities. Lineages associated with outbreak clusters in 2 counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain SARS-CoV-2 spread in California and other states.

  • 原文来源：https://science.sciencemag.org/content/early/2020/06/05/science.abb9263
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