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《LANCET，3月17日，Clinical course and mortality risk of severe COVID-19》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-18

  • Clinical course and mortality risk of severe COVID-19

    Paul Weiss

    David R Murdoch

    Published:March 17, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30633-4

    Several published reports of early clinical descriptions of coronavirus disease 2019 (COVID-19) have emerged from Hubei province in China, and many more will come. These early reports, typically simple descriptive case series of patients hospitalised with COVID-19 (mostly with pneumonia), provide valuable information on the more severe end of the disease spectrum. We tend to hear more about the most severe cases in the early stages of a new disease, as these are the ones first brought to the public's attention and are associated with deaths.

  • 原文来源：https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30633-4/fulltext
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    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
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  • 《LANCET，3月17日，COVID-19 in pregnant women – Authors' reply》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-18
    • COVID-19 in pregnant women – Authors' reply David Baud Eric Giannoni Léo Pomar Xiaolong Qi Karin Nielsen-Saines Didier Musso et al. Show all authors Published:March 17, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30192-4 We are grateful for the concerns of Manuel Schmidt and colleagues about our previous guidelines1 for pregnant women with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. At the time we developed the algorithm (February, 2020), there were no data regarding potential vertical transmission from infected mothers and outcomes in newborns. To date, there has been no evidence of vertical transmission of coronavirus disease 2019 (COVID-19) based on two small clinical series.2, 3 According to WHO, delayed umbilical cord clamping is highly unlikely to increase the risk of transmitting pathogens from the mother to the fetus even in the case of maternal infection.4 Because the vernix caseosa contains antimicrobial peptides, we recommend leaving it in place until 24 h after birth.5 New data examining neonates from infected mothers could be reassuring, but transmission after birth via contact with infectious respiratory secretions is still a concern, and physical separation of mother from child should be considered. Separation is a standard practice in pulmonary tuberculosis and is discussed in cases of maternal influenza infection.6 Therefore, separation of the mother and her newborn baby should be individually discussed by an interdisciplinary team, considering local facilities and risk factors for adverse neonatal outcomes, such as prematurity and fetal distress.
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