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《J Infection，6月21日，Diagnostic accuracy of the FebriDx host response point-of-care test in patients hospitalised with suspected COVID-19》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-06-22

  • Diagnostic accuracy of the FebriDx host response point-of-care test in patients hospitalised with suspected COVID-19

    Author links open overlay panelTristan W.ClarkabcdNathan JBrendishabStephenPooleabcVasanth V.NaidubChristopherMansbridgebNicholasNortonbHelenWheelercLauraPreslandcSeanEwingse

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    https://doi.org/10.1016/j.jinf.2020.06.051

    Abstract

    Introduction

    Management of the COVID-19 pandemic is hampered by long delays associated with centralised laboratory PCR testing. In hospitals this leads to poor patient flow and nosocomial transmission and so rapid, accurate diagnostic tests are urgently required. The FebriDx is a point-of-care test that detects an antiviral host response protein in finger prick blood within 10 minutes, but its accuracy for the identification of COVID-19 is unknown.

    Methods

    We performed a real-world diagnostic accuracy study of FebriDx in hospitalised patients during the first wave of the pandemic. Measures of diagnostic accuracy were calculated based on FebriDx results compared to the reference standard of SARS-CoV-2 PCR on combined nose and throat swabs. A multivariable predictive model including FebriDx, age, sex, and clinical characteristics was developed and underwent internal validation.

  • 原文来源：https://www.sciencedirect.com/science/article/pii/S0163445320304321
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    • 编译者：zhangmin
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