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《Nature，11月10日，Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-11-18

  • Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility
    Fang Wang, Shujia Huang, […]Lei Liu
    Cell Discovery volume 6, Article number: 83 (2020)

    Abstract
    The COVID-19 pandemic has accounted for millions of infections and hundreds of thousand deaths worldwide in a short-time period. The patients demonstrate a great diversity in clinical and laboratory manifestations and disease severity. Nonetheless, little is known about the host genetic contribution to the observed interindividual phenotypic variability. Here, we report the first host genetic study in the Chinese population by deeply sequencing and analyzing 332 COVID-19 patients categorized by varying levels of severity from the Shenzhen Third People’s Hospital. Upon a total of 22.2 million genetic variants, we conducted both single-variant and gene-based association tests among five severity groups including asymptomatic, mild, moderate, severe, and critical ill patients after the correction of potential confounding factors. Pedigree analysis suggested a potential monogenic effect of loss of function variants in GOLGA3 and DPP7 for critically ill and asymptomatic disease demonstration.

  • 原文来源：https://www.nature.com/articles/s41421-020-00231-4
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