登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《BioRxiv，3月2日，Mutations, Recombination and Insertion in the Evolution of 2019-nCoV》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-03

  • Mutations, Recombination and Insertion in the Evolution of 2019-nCoV

    Aiping Wu, Peihua Niu, Lulan Wang, Hangyu Zhou, Xiang Zhao, Wenling Wang, Jingfeng Wang, Chengyang Ji, Xiao Ding, Xianyue Wang, Roujian Lu, Sarah Gold, Saba Aliyari, Shilei Zhang, Ellee Vikram, Angela Zou, Emily Lenh, Janet Chen, Fei Ye, Na Han, Yousong Peng, Haitao Guo, Guizhen Wu, Taijiao Jiang, Wenjie Tan, Genhong Cheng

    doi: https://doi.org/10.1101/2020.02.29.971101

    Abstract

    Background: The 2019 novel coronavirus (2019-nCoV or SARS-CoV-2) has spread more rapidly than any other betacoronavirus including SARS-CoV and MERS-CoV. However, the mechanisms responsible for infection and molecular evolution of this virus remained unclear. Methods: We collected and analyzed 120 genomic sequences of 2019-nCoV including 11 novel genomes from patients in China. Through comprehensive analysis of the available genome sequences of 2019-nCoV strains, we have tracked multiple inheritable SNPs and determined the evolution of 2019-nCoV relative to other coronaviruses.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.02.29.971101v1
81浏览量
原文链接
相关报告

  • 《bioRxiv，2月18日，Recombination and convergent evolution led to the emergence of 2019 Wuhan coronavirus》
    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-02-19
    • Recombination and convergent evolution led to the emergence of 2019 Wuhan coronavirus Juan Angel Patino-Galindo, Ioan Filip, Mohammed AlQuraishi, Raul Rabadan doi: https://doi.org/10.1101/2020.02.10.942748 Abstract The recent outbreak of a new coronavirus (2019-nCoV) in Wuhan, China, underscores the need for understanding the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. Here, we show that recombination in betacoronaviruses, including human-infecting viruses like SARS and MERS, frequently encompasses the Receptor Binding Domain (RBD) in the Spike gene. We find that this common process likely led to a recombination event at least 11 years ago in an ancestor of the 2019-nCoV involving the RBD. Compared with bat isolates, the recent ancestors of 2019-nCoV accumulated a high number of amino acid substitutions in the RBD and likewise in a region of polyprotein Orf1a that is critical for viral replication and transcription. Among these recent mutations, we identify amino acid substitutions common to the SARS 2003 outbreak isolates in positions 427N and 436Y, indicating potential adaptive convergent evolution. Both 427N and 436Y belong to a helix that appears to interact with the human ACE2 receptor. In sum, we propose a two-hit scenario in the emergence of the 2019-nCoV virus whereby the 2019-nCoV ancestors in bats first acquired genetic characteristics of SARS by incorporation of a SARS-like RBD through recombination before 2009, and subsequently, those recombinants underwent convergent evolution. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    57浏览量
    原文链接

  • 《BioRxiv，3月2日，Predictions for the binding domain and potential new drug targets of 2019-nCoV》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-03
    • Predictions for the binding domain and potential new drug targets of 2019-nCoV Zehua Zeng, Luo Zhi, Hongwu Du doi: https://doi.org/10.1101/2020.02.26.961938 Abstract An outbreak of new SARS-like viral in Wuhan, China has been named 2019-nCoV. The current state of the epidemic is increasingly serious, and there has been the urgent necessity to develop an effective new drug. In previous studies, it was found that the conformation change in CTD1 was the region where SARS-CoV bound to human ACE2. Although there are mutations of the 2019-nCoV, the binding energy of ACE2 remains high. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    58浏览量
    原文链接