登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《BioRxiv，3月2日，Predictions for the binding domain and potential new drug targets of 2019-nCoV》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-03

  • Predictions for the binding domain and potential new drug targets of 2019-nCoV

    Zehua Zeng, Luo Zhi, Hongwu Du

    doi: https://doi.org/10.1101/2020.02.26.961938

    Abstract

    An outbreak of new SARS-like viral in Wuhan, China has been named 2019-nCoV. The current state of the epidemic is increasingly serious, and there has been the urgent necessity to develop an effective new drug. In previous studies, it was found that the conformation change in CTD1 was the region where SARS-CoV bound to human ACE2. Although there are mutations of the 2019-nCoV, the binding energy of ACE2 remains high.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.02.26.961938v1
69浏览量
原文链接
相关报告

  • 《BioRxiv，3月31日，Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-04-01
    • Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2 Cheng Wang, Shaobo Wang, Daixi Li, Xia Zhao, Songling Han, Tao Wang, Gaomei Zhao, Yin Chen, Fang Chen, Jianqi Zhao, Liting Wang, Wei Sun, Yi Huang, Yongping Su, Dongqing Wei, Jinghong Zhao, Junping Wang doi: https://doi.org/10.1101/2020.03.29.013490 Abstract The burgeoning epidemic caused by novel coronavirus 2019 (2019-nCoV) is currently a global concern. Angiotensin-converting enzyme-2 (ACE2) is a receptor of 2019-nCoV spike 1 protein (S1) and mediates viral entry into host cells. Despite the abundance of ACE2 in small intestine, few digestive symptoms are observed in patients infected by 2019-nCoV. Herein, we investigated the interactions between ACE2 and human defensins (HDs) specifically secreted by intestinal Paneth cells. The lectin-like HD5, rather than HD6, bound ACE2 with a high affinity of 39.3 nM and weakened the subsequent recruitment of 2019-nCoV S1. The cloak of HD5 on the ligand-binding domain of ACE2 was confirmed by molecular dynamic simulation. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    43浏览量
    原文链接

  • 《LANCET，2月7日，Pandemic potential of 2019-nCoV》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-02-09
    • Pandemic potential of 2019-nCoV Robin Thompson Published:February 07, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30068-2 An important determinant of whether or not 2019 novel coronavirus (2019-nCoV) will ultimately cause a global pandemic is its ability to become established upon its importation to a new country. Cases of 2019-nCoV infection have so far been reported in 24 countries, yet little human-to-human transmission outside of China has occurred.
    93浏览量
    原文链接