Cardiovascular medications and regulation of Covid-19 receptors expression
Author links open overlay panelNarjes SahebSharif-AskariaFatemeh SahebSharif-AskariaSabaAl HeialybeRifatHamoudiacTarekKashourdQutaybaHamidaceRabihHalwaniacf
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https://doi.org/10.1016/j.ijchy.2020.100034
Abstract
Introduction
Emerging epidemiological studies suggested that Renin–Angiotensin–Aldosterone system (RAAS) inhibitors may increase infectivity and severity of COVID-19 by modulating the expression of ACE2.
Methods
In silico analysis was conducted to compare the blood expression levels of SARS-CoV-2 entry genes between age and gender matched cohort of hypertensive patients versus control, and to determine the effect of common cardiovascular medications on the expression of Covid-19 receptors in vitro using primary human hepatocytes.
