Clinical Course and Outcomes of Critically Ill Patients of 2019 Novel Coronavirus Pneumonia
19 Pages Posted: 6 Feb 2020
Corresponding Author: You Shang, Ph.D., M.D.
Wuhan Union Hospital
Wuhan, Hubei CHINA
First Author: Xiaobo Yang
Abstract
Background: An ongoing outbreak of pneumonia associated with the 2019 novel coronavirus (2019-nCoV) started in December 2019, in Wuhan, China. Information on critically ill patients of 2019-nCoV infection is extremely limited. We aimed to describe the clinical course and outcomes of critically ill patients of 2019-nCoV pneumonia.
Methods: In this retrospective study, 52 critically ill patients out of 710 patients, who were diagnosed with 2019-nCoV pneumonia in Wuhan Jinyintan Hospital between the onset of the outbreak and January 26, 2020, were investigated. Only patients treated with high flow nasal cannula or mechanical ventilator were included. Patients who were deceased or who had been hospitalized for at least 14 days were considered for the case reviewed. Epidemiological, demographic, clinical and laboratory data were collected and analyzed to explore the differences between survivors and non-survivors.
Findings: Of the 52 critically ill patients, the average age was 59.7 ±13.3 years(mean ± standard deviation), 35 (67.3%) were male, 21 (40.4%) had chronic illness, 51 (98.1%) had fever, 35 (67.3%) had ARDS and 37 (71.2%) required mechanical ventilation. The duration from onset of symptoms to radiological diagnosis of pneumonia was 5 [3-7] (median [interquartile range]) days. Thirty-three (57.7%) patients deceased, and the duration from hospital admission to death was 7 [3 - 11] days. Compared with survivors, non-survivors were older (64.7 ± 11.1 years vs 59.7 ± 13.3 years, p = 0.001), received higher fraction of oxygen therapy (0.87 ± 0.16 vs 0.70 ± 0.18, p = 0.004), developed more ARDS (83.3% vs 45.4%, p = 0.007), required more mechanical ventilation (93.3% vs 40.9%, p = 0.003) and were more likely to be on extracorporeal membrane oxygenation (16.7% vs 4.6%, p = 0.06).
