登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《Nature，4月28日，Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-04-29

  • Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient

    Xiao-Hong Yao, Zhi-Cheng He, Ting-Yuan Li, Hua-Rong Zhang, Yan Wang, Huaming Mou, Qiaonan Guo, Shi-Cang Yu, Yanqing Ding, Xindong Liu, Yi-Fang Ping & Xiu-Wu Bian

    Cell Research (2020)

    SARS-CoV-2, a novel coronavirus and causing COVID-19, has given rise to a worldwide pandemic.1,2 So far, tens of thousands of COVID-19 patients have been clinically cured and discharged, but multiple COVID-19 cases showed SARS-CoV-2 positive again in discharged patients,3 which raises an attention for the discharged patients. Also, there is an urgent need to understand the pathogenesis of SARS-CoV-2 infection. Here, we conducted postmortem pathologic study in a ready-for-discharge COVID-19 patient who succumbed to sudden cardiovascular accident. Pathological examination revealed SARS-CoV-2-viruses remaining in pneumocytes and virus-caused pathological changes in the lungs. Our study provided new insights into SARS-CoV-2 pathogenesis and might facilitate the improvement of clinical guideline for virus containment and disease management.

  • 原文来源：https://www.nature.com/articles/s41422-020-0318-5
10浏览量
原文链接
相关报告

  • 《Nature，5月4日，A human monoclonal antibody blocking SARS-CoV-2 infection》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-05-05
    • A human monoclonal antibody blocking SARS-CoV-2 infection Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M. A. Okba, Rien van Haperen, Albert D. M. E. Osterhaus, Frank J. M. van Kuppeveld, Bart L. Haagmans, Frank Grosveld & Berend-Jan Bosch Nature Communications volume 11, Article number: 2251 (2020) Abstract The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.
    298浏览量
    原文链接

  • 《Virus Evolution，4月30日，No evidence for distinct types in the evolution of SARS-CoV-2》
    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-05-02
    • No evidence for distinct types in the evolution of SARS-CoV-2 Oscar A MacLean, Richard J Orton, Joshua B Singer, David L Robertson Virus Evolution, veaa034, https://doi.org/10.1093/ve/veaa034 Published: 30 April 2020 Article history Abstract A recent study by Tang et al. (2020) claimed that two major types of SARS-CoV-2 had evolved in the ongoing COVID-19 pandemic and that one of these types was more “aggressive” than the other. Given the repercussions of these claims and the intense media coverage of these types of articles, we have examined in detail the data presented by Tang et al, and show that the major conclusions of that paper cannot be substantiated. Using examples from other viral outbreaks we discuss the difficulty in demonstrating the existence or nature of a functional effect of a viral mutation, and we advise against overinterpretation of genomic data during the pandemic.
    9浏览量
    原文链接