《JAMA,5月15日,Reopening Society and the Need for Real-Time Assessment of COVID-19 at the Community Level》

  • 来源专题:COVID-19科研动态监测
  • 编译者: xuwenwhlib
  • 发布时间:2020-05-16
  • Reopening Society and the Need for Real-Time Assessment of COVID-19 at the Community Level

    Frederick J. Angulo, DVM, PhD1; Lyn Finelli, DrPH, MS2; David L. Swerdlow, MD1

    Author Affiliations Article Information

    JAMA. Published online May 15, 2020. doi:10.1001/jama.2020.7872

    Through May 13, 2020, approximately 1.39 million cases of coronavirus disease 2019 (COVID-19) have been reported in the United States (by the Centers for Disease Control and Prevention) and more than 4.3 million cases of COVID-19 have been reported from 188 countries.1 There is an urgent need for COVID-19 data, including community-level incidence, spectrum of disease, diagnostic test penetration, and proportion of the community with protective immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (herd immunity). These data are vital to understanding where communities are on the continuum of COVID-19 cumulative incidence and prevalence and how nonpharmaceutical interventions can be titrated to reopen business and society. Real-time incidence and seroepidemiologic data are also essential to plan scenarios for the development of COVID-19 vaccines and therapeutics. Cross-sectional community surveys combined with seroepidemiology can help inform the present and help navigate the path forward.

  • 原文来源:https://jamanetwork.com/journals/jama/fullarticle/2766293
相关报告
  • 《Science,5月5日,Rapid implementation of mobile technology for real-time epidemiology of COVID-19》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-05-06
    • Rapid implementation of mobile technology for real-time epidemiology of COVID-19 David A. Drew1,*, Long H. Nguyen1,*, Claire J. Steves2,3, Cristina Menni2, Maxim Freydin2, Thomas Varsavsky4, Carole H. Sudre4, M. Jorge Cardoso4, Sebastien Ourselin4, Jonathan Wolf5, Tim D. Spector2,5,†, Andrew T. Chan1,6,†,‡, COPE Consortium§ See all authors and affiliations Science 05 May 2020: eabc0473 DOI: 10.1126/science.abc0473 Abstract The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (COVID-19) presents challenges to the robust collection of population-scale data to address this global health crisis. We established the COronavirus Pandemic Epidemiology (COPE) consortium to bring together scientists with expertise in big data research and epidemiology to develop a COVID-19 Symptom Tracker mobile application that we launched in the UK on March 24, 2020 and the US on March 29, 2020 garnering more than 2.8 million users as of May 2, 2020. This mobile application offers data on risk factors, herald symptoms, clinical outcomes, and geographical hot spots. This initiative offers critical proof-of-concept for the repurposing of existing approaches to enable rapidly scalable epidemiologic data collection and analysis which is critical for a data-driven response to this public health challenge.
  • 《5月15日_辉瑞和默克公司讨论重新开放社会与社区一级对COVID-19进行实时评估的必要性》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-05-17
    • 1.时间:2020年5月15日 2.机构或团队:辉瑞疫苗医学开发和科学/临床事务部、默克公司观察性与现实世界证据中心 3.事件概要: 5月15日,JAMA期刊在线发表了辉瑞和默克公司的观点文章“Reopening Society and the Need for Real-Time Assessment of COVID-19 at the Community Level”。 文章指出,快速社区调查已被世界卫生组织和其他组织广泛用于快速评估健康状况,例如免疫接种覆盖率或进行人口统计调查。在社区COVID-19快速调查中,将对选中的个人进行指定日期的询问,询问他们或他们的家庭成员是否具有COVID-19症状,是否曾寻就医、接受过检测、住院、重症监护室住院或经历了通气,以及家庭成员是否死亡。如果在调查时收集了血液样本和上呼吸道样本,则可以估算出具有SARS-CoV-2抗体的社区比例,以及过去和当前感染的有症状的社区比例。这些数据对于确定先前的社区缓解策略的有效性以及未来此类策略的方向至关重要。可以将快速调查中有症状的人的比例与血清学结果进行比较,以估计无症状感染SARS-CoV-2的人的比例。 文章指出,政策、公共卫生计划和干预措施制定需要对社区未来COVID-19情景进行预测。社区将需要预测未来的情景,以调整非药物干预措施的强度,并决定何时重新开放企业和学校。另外,有关基线免疫水平的信息对于规划疫苗和治疗剂的临床试验很重要。社区和血清流行病学调查与建模方法相结合是预测未来情况的有用工具。许多研究小组已经开发了国家和地方COVID-19情景预测模型。尽管这些模型一直存在争议,但社区和流行病学调查可以获取数据,减少基本假设的不确定性。 在社区一级对COVID-19的准确评估需要可靠的证据来证明接受过COVID-19检测的有症状人员的比例、无症状病例的比例、COVID-19累计发病率、住院患者的比例以及死亡比例。确定非药物干预以及开发COVID-19疫苗和治疗剂需要对抗体水平和群体免疫力进行连续测量。综合社区和流行病学调查,结合建模和乘数方法,以估计社区一级COVID-19的发病率和流行率,对于评估大流行的现状,规划当前的和未来的干预措施以及为社区逐步恢复到正常活动提供决策依据至关重要。 4.附件: 原文链接:https://jamanetwork.com/journals/jama/fullarticle/2766293