Estimating underdetection of internationally imported COVID-19 cases
Pablo M De Salazar, Rene Niehus, Aimee Taylor, Marc Lipsitch
doi: https://doi.org/10.1101/2020.02.13.20022707
Abstract
Risk of COVID-19 infection in Wuhan has been estimated using imported case counts of international travelers, often under the assumption that all cases in travelers are ascertained. Recent work indicates variation among countries in detection capacity for imported cases. Singapore has historically had very strong epidemiological surveillance and contact-tracing capacity and has shown in the COVID-19 epidemic evidence of a high sensitivity of case detection. We therefore used a Bayesian modeling approach to estimate the relative imported case detection efficiency for other countries compared to that of Singapore. We estimate that the global ability to detect imported cases is 38% (95% HPDI 22% - 64%) of Singapore′s capacity. Equivalently, an estimate of 2.8 (95% HPDI 1.5 - 4.4) times the current number of imported cases, could have been detected, given all countries had the same detection capacity as Singapore. Using the second component of the Global Health Security index to stratify country likely detection capacities, we found that the ability to detect imported cases among high surveillance countries is 40% (95% HPDI 22% - 67%), among intermediate surveillance countries it is 37% (95% HPDI 18% - 68%), and among low surveillance countries it is 11% (95% HPDI 0% - 42%). We conclude that estimates of case counts in Wuhan based on assumptions of perfect detection in travelers may be underestimated by several fold, and severity correspondingly overestimated by several fold. Undetected cases are likely in countries around the world, with greater risk in countries of low detection capacity and high connectivity to the epicenter of the outbreak.
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