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《European Heart J，3月20日，SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-23

  • SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19?

    Gabriela M Kuster, Otmar Pfister, Thilo Burkard, Qian Zhou, Raphael Twerenbold, Philip Haaf, Andreas F Widmer, Stefan Osswald

    European Heart Journal, ehaa235, https://doi.org/10.1093/eurheartj/ehaa235

    Published: 20 March 2020

    In a rapid response published online by the British Medical Journal, Sommerstein and Gräni1 pushed forward the hypothesis that angiotensin-converting enzyme (ACE) inhibitors (ACE-Is) could act as a potential risk factor for fatal Corona virus disease 2019 (COVID-19) by up-regulating ACE2. This notion was quickly picked up by the lay press and sparked concerns among physicians and patients regarding the intake of inhibitors of the renin–angiotensin–aldosterone system (RAAS) by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infected individuals.1 In this article, we try to shed light on what is known and unknown regarding the RAAS and SARS-CoV2 interaction.

  • 原文来源：https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa235/5810479?searchresult=1
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    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
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    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-04-04
    • Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic Andrew M. South, Laurie Tomlinson, Daniel Edmonston, Swapnil Hiremath & Matthew A. Sparks Nature Reviews Nephrology (2020) The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-CoV-2 — gains entry to host cells via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship between the virus and the renin–angiotensin system (RAS) and how this might be affected by RAS inhibitors.
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