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《CID，5月15日，An inflammatory profile correlates with decreased frequency of cytotoxic cells in COVID-19》

  • 来源专题：COVID-19科研动态监测
  • 编译者： xuwenwhlib
  • 发布时间：2020-05-17

  • An inflammatory profile correlates with decreased frequency of cytotoxic cells in COVID-19

    Veronica Bordoni, Alessandra Sacchi, Eleonora Cimini, Stefania Notari, Germana Grassi, Eleonora Tartaglia, Rita Casetti, Letizia Giancola, Nazario Bevilacqua, Markus Maeurer ... Show moreAuthor Notes

    Clinical Infectious Diseases, ciaa577, https://doi.org/10.1093/cid/ciaa577

    Published: 15 May 2020 Article history

    Abstract

    Increased production of inflammatory cytokines and myeloid-derived suppressor cells occur in COVID-19 patients. These inversely correlated with perforin-expressing NK and CD3+T-cells. We observed a lower perforin+ NK cells number in intensive care unit (ICU) compared to non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.

  • 原文来源：https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa577/5837139?searchresult=1
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