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《Science，10月9日，REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-10-15

  • REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

    Alina Baum1, View ORCID ProfileDharani Ajithdoss1, Richard Copin1, Anbo Zhou1, Kathryn Lanza1, Nicole Negron1, Min Ni1, Yi Wei1, View ORCID ProfileKu...

    Science 09 Oct 2020:

    eabe2402

    DOI: 10.1126/science.abe2402

    Abstract

    An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in lower and upper airways and decrease virus induced pathological sequalae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.

  • 原文来源：https://science.sciencemag.org/content/early/2020/10/08/science.abe2402
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  • 《10月9日_再生元REGN-COV2抗体可预防和治疗恒河猴和仓鼠的SARS-CoV-2感染》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-10-15
    • Science期刊于10月9日发布了再生元制药、德克萨斯州生物医学研究所等机构的研究文章“REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters”。再生元制药先前介绍了两种靶向SARS-CoV-2刺突蛋白的不重叠表位的有效中和抗体（REGN10987 + REGN10933）的混合物REGN-COV2。在本研究报告中，该团队评估了该抗体混合物在恒河猴（可能模拟轻度疾病）和金仓鼠（可能模拟较严重疾病）中的功效。研究人员证明，当在恒河猴中进行预防性或治疗性给药时，REGN-COV-2可以大大降低下呼吸道和上呼吸道的病毒载量，并减少病毒引起的病理性疱疹。同样，对仓鼠进行给药可限制体重减轻，降低肺滴度和肺炎迹象。报告称，该结果提供了该抗体混合物的治疗潜力的证据。 原文链接：https://science.sciencemag.org/content/early/2020/10/08/science.abe2402
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  • 《Science，5月20日，SARS-CoV-2 infection protects against rechallenge in rhesus macaques》
    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-05-21
    • SARS-CoV-2 infection protects against rechallenge in rhesus macaques View ORCID ProfileAbishek Chandrashekar1,*, View ORCID ProfileJinyan Liu1,*, View ORCID ProfileAmanda J. Martinot1,2,*, View ORCID ProfileKatherine McMahan1,*, View ORCID ProfileNoe B. Mercado1,*, View ORCID ProfileLauren Peter1,*, View ORCID ProfileLisa H. Tostanoski1,*, View ORCID ProfileJingyou Yu1,*, View ORCID ProfileZoltan Maliga3, Michael Nekorchuk4, View ORCID ProfileKathleen Busman-Sahay4, View ORCID ProfileMargaret Terry4, View ORCID ProfileLinda M. Wrijil2, View ORCID ProfileSarah Ducat2, David R. Martinez5, View ORCID ProfileCaroline Atyeo3,6, View ORCID ProfileStephanie Fischinger6, View ORCID ProfileJohn S. Burke6, View ORCID ProfileMatthew D. Slein6, View ORCID ProfileLaurent Pessaint7, View ORCID ProfileAlex Van Ry7, View ORCID ProfileJack Greenhouse7, View ORCID ProfileTammy Taylor7, View ORCID ProfileKelvin Blade7, Anthony Cook7, View ORCID ProfileBrad Finneyfrock7, Renita Brown7, Elyse Teow7, Jason Velasco7, View ORCID ProfileRoland Zahn8, View ORCID ProfileFrank Wegmann8, View ORCID ProfilePeter Abbink1, View ORCID ProfileEsther A. Bondzie1, View ORCID ProfileGabriel Dagotto1,3, View ORCID ProfileMakda S. Gebre1,3, Xuan He1, View ORCID ProfileCatherine Jacob-Dolan1,3, View ORCID ProfileNicole Kordana1, Zhenfeng Li1, View ORCID ProfileMichelle A. Lifton1, View ORCID ProfileShant H. Mahrokhian1, View ORCID ProfileLori F. Maxfield1, View ORCID ProfileRamya Nityanandam1, View ORCID ProfileJoseph P. Nkolola1, View ORCID ProfileAaron G. Schmidt6,9, View ORCID ProfileAndrew D. Miller10, View ORCID ProfileRalph S. Baric5, View ORCID ProfileGalit Alter6,9, View ORCID ProfilePeter K. Sorger3, View ORCID ProfileJacob D. Estes4, View ORCID ProfileHanne Andersen7, View ORCID ProfileMark G. Lewis7, View ORCID ProfileDan H. Barouch1,6,9,† See all authors and affiliations Science 20 May 2020: eabc4776 DOI: 10.1126/science.abc4776 Abstract An understanding of protective immunity to SARS-CoV-2 is critical for vaccine and public health strategies aimed at ending the global COVID-19 pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against re-exposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. Following initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with primary infection. Anamnestic immune responses following rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against re-exposure in nonhuman primates.
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