《Nature,2月18日,When will the coronavirus outbreak peak?》

  • 来源专题:COVID-19科研动态监测
  • 编译者: xuwenwhlib
  • 发布时间:2020-02-19
  • When will the coronavirus outbreak peak?

    Officials want to know but predictions vary wildly, from now to after hundreds of millions of people are infected.

    Coronavirus infections in China continue to swell by thousands a day, prompting epidemiologists to estimate when the outbreak will peak. Some suggest the climax, when the number of new infections in a single day reaches its highest point, will happen any time now. Others say that it is months away and that the virus will infect millions — or in one estimate hundreds of millions — of people first.

    Public health officials want to know roughly when the peak will be — and how many will be infected — so that they can prepare hospitals and know when it will be safe to lift travel restrictions. Wuhan, the city at the centre of the epidemic, and several other nearby cities have been on lockdown since late January.

    Although peak predictions can be illuminating, some researchers warn that accuracy is difficult to achieve, especially when the data used in models are incomplete. “If you revise your predictions every week to say that the outbreak will peak in a week or two, eventually you will be correct,” says Brian Labus, who works on disease surveillance at the University of Nevada, Las Vegas.

    Optimistic scenario

    On 11 February, Zhong Nanshan, a prominent Chinese physician leading a panel of experts helping to control the outbreak, said that the coronavirus will possibly peak by the end of February. Zhong, who is famous for discovering the SARS virus, said the situation had improved with government control measures, such as travel restrictions and extended holidays, although he admitted that it was still a “difficult period” for Wuhan.

  • 原文来源:https://www.nature.com/articles/d41586-020-00361-5
相关报告
  • 《Nature,2月18日,Coronavirus latest: has the outbreak in China peaked?》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-02-19
    • Coronavirus latest: has the outbreak in China peaked? Scientists are concerned about a new virus that has infected tens of thousands of people and killed more than 1,000. The virus, which emerged in the Chinese city of Wuhan in December, is a coronavirus and belongs to the same family as the pathogen that causes severe acute respiratory syndrome, or SARS. It causes a respiratory illness called COVID-19, which can spread from person to person. Here’s the latest news on the outbreak. 18 February 11:00 GMT — Has the outbreak peaked in China? A study of nearly 45,000 confirmed COVID-19 infections in China suggests that the outbreak might already have reached its climax . The report, from the country’s Centre for Disease Control and Prevention, says that the day with the highest number of new infections — known as the peak — occurred around the end of January; since then, the number of new confirmed cases per day has declined. However, the number of new suspected cases and those cases diagnosed by physicians using chest images, known as clinically diagnosed cases, stayed at roughly the same levels each day over the study period, which ended on 11 February. The latest data on coronavirus infections in China appears to show a decline in new cases, said Tedros Adhanom Ghebreyesus, the World Health Organization’s (WHO) director-general, at a press briefing on the same day. But he said the trend must be interpreted cautiously. “It’s too early to tell if this new reported decline will continue,” he said. “Every scenario is still on the table.” Raina MacIntyre, a physician and epidemiologist at the University of New South Wales in Sydney, Australia, agrees that data need to be considered with caution, but says the general trends are informative. The WHO’s reports also show a decline in new cases reported per day in China and worldwide, she says. But the extended holiday period in China that ended on 9 February means there might be another increase in new cases around 21 February, as people return to work. “Often with epidemics we see more than one peak,” says MacIntyre. Epidemiologists have been trying to estimate roughly when the outbreak will peak. Public-health officials want to know this so they can prepare hospitals and know when it will be safe to lift travel restrictions in Wuhan and several nearby cities. Some models suggest that the climax will happen any time now. Others say that it is months away and that the virus will infect millions — or, in one estimate, hundreds of millions — of people before then. This model assumes that many more people have been infected than the official counts, but that these people are asymptomatic or not ill enough to seek medical treatment. The coronavirus SARS-CoV-2, shown in a scanning-electron-microscope image.Credit: NIAID-RML/de Wit/Fischer
  • 《 MedRxiv,2月18日,When will the battle against novel coronavirus end in Wuhan: a SEIR modeling analysis》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-02-19
    • When will the battle against novel coronavirus end in Wuhan: a SEIR modeling analysis lianglu zhang Sr., kangkang wan Jr., jing chen Sr., changming lu Sr., lanlan dong Jr., zhicheng wu Sr. doi: https://doi.org/10.1101/2020.02.16.20023804 Abstract Recent outbreak of 2019-nCoV in Wuhan raised serious public health concerns. By February 15, 2020 in Wuhan, the total number of confirmed infection cases has reached 37,914, and the number of deaths has reached 1123, accounting for 56.9% of the total confirmed cases and 73.7% of the total deaths in China. People are eager to know when the epidemic will be completely controlled and when people's work and life will be on the right track. In this study we analyzed the epidemic dynamics and trend of 2019-nCoV in Wuhan by using the data after the closure of Wuhan city till February 12, 2020 based on the SEIR modeling method. The optimal parameters were estimated as R0=1.44 (interquartile range: 1.40-1.47),TI=14 (interquartile range: 14-14) and TE=3.0 (interquartile range: 2.8-3.1). Based on these parameters, the number of infected individuals in Wuhan city may reach the peak around February 19 at about 45,000 people. Once entering March, the epidemic would gradually decline, and end around the late March. It is worth noting that the above prediction is based on the assumption that the number of susceptible population N = 200,000 will not increase. If the epidemic situation is not properly controlled, the peak of infected number can be further increased and the peak time will be a little postponed. It was expected that the epidemic would subside in early March, and disappear gradually towards the late March. *注,本文为预印本论文手稿,是未经同行评审的初步报告,其观点仅供科研同行交流,并不是结论性内容,请使用者谨慎使用.