《NEJM,4月8日,Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19》

  • 来源专题:COVID-19科研动态监测
  • 编译者: xuwenwhlib
  • 发布时间:2020-04-09
  • Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

    April 8, 2020

    DOI: 10.1056/NEJMc2007575

    To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations for evaluation or treatment. In the interest of timeliness, these reports are evaluated by in-house editors, with peer review reserved for key points as needed.

    We describe a patient with Covid-19 and clinically significant coagulopathy, antiphospholipid antibodies, and multiple infarcts. He was one of three patients with these findings in an intensive care unit designated for patients with Covid-19. This unit, which was managed by a multidisciplinary team from Peking Union Medical College Hospital in the Sino–French New City Branch of Tongji Hospital in Wuhan, China, was set up on an emergency basis to accept the most critically ill patients during the outbreak of Covid-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was confirmed in all the patients by reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay or serologic testing.

  • 原文来源:https://www.nejm.org/doi/full/10.1056/NEJMc2007575?query=featured_coronavirus
相关报告
  • 《NEJM,6月17日,Genomewide Association Study of Severe Covid-19 with Respiratory Failure》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-06-19
    • Genomewide Association Study of Severe Covid-19 with Respiratory Failure List of authors. David Ellinghaus, Ph.D., Frauke Degenhardt, M.Sc., Luis Bujanda, M.D., Ph.D., Maria Buti, M.D., Ph.D., Agustín Albillos, M.D., Ph.D., Pietro Invernizzi, M.D., Ph.D., Javier Fernández, M.D., Ph.D., Daniele Prati, M.D., Guido Baselli, Ph.D., Rosanna Asselta, Ph.D., Marit M. Grimsrud, M.D., Chiara Milani, Ph.D., et al., for The Severe Covid-19 GWAS Group* June 17, 2020 DOI: 10.1056/NEJMoa2020283 Abstract BACKGROUND There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. METHODS We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels. RESULTS We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P<5×10−8) in the meta-analysis of the two case–control panels (odds ratio, 1.77; 95% confidence interval [CI], 1.48 to 2.11; P=1.15×10−10; and odds ratio, 1.32; 95% CI, 1.20 to 1.47; P=4.95×10−8, respectively). At locus 3p21.31, the association signal spanned the genes SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6 and XCR1. The association signal at locus 9q34.2 coincided with the ABO blood group locus; in this cohort, a blood-group–specific analysis showed a higher risk in blood group A than in other blood groups (odds ratio, 1.45; 95% CI, 1.20 to 1.75; P=1.48×10−4) and a protective effect in blood group O as compared with other blood groups (odds ratio, 0.65; 95% CI, 0.53 to 0.79; P=1.06×10−5). CONCLUSIONS We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system. (Funded by Stein Erik Hagen and others.)
  • 《CELL,4月8日,Epidemiological and clinical characteristics of COVID-19 in adolescents and young adults》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-04-09
    • Epidemiological and clinical characteristics of COVID-19 in adolescents and young adults Jiaqiang Liao, Ph.D.1#* , Shibing Fan, MD.2#, Jing Chen, BD.3# , Jianglin Wu, BD.4# Public summary ? Adolescents and young adults are more involved in frequent socialactivity, overseas studying, and international working and traveling, which might make them susceptible to worldwide spread of the coronavirus disease 2019 (COVID-19). ? Adolescent and younger patients of COVID-19 had a median incubation period of 8 days and 50% of their family contacts could develop illness within 1.4 days after exposure. ? Three asymptomatic patients of COVID-19 have infected their family contacts. ? Although most of the adolescent and young adult patients of COVID-19 have better prognosis outcomes after treatment, few of them showed severe clinical signs and symptoms such as bacterial pneumonia changes by Chest CT findings, fever, and shortness of breath.