登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《Nature，3月24日，COVID-19: protect great apes during human pandemics》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-25

  • SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic, is also a threat to our closest living relatives, the great apes. As leading experts in the conservation and health of these animals, we urge governments, conservation practitioners, researchers, tourism professionals and funding agencies to reduce the risk of introducing the virus into these endangered apes. They can do this by applying the International Union for Conservation of Nature’s best-practice guidelines for health monitoring and disease control in great-ape populations (see go.nature.com/3b1bq9k).

  • 原文来源：https://www.nature.com/articles/d41586-020-00859-y
6浏览量
原文链接
相关报告

  • 《Nature，3月29日，The spatial landscape of lung pathology during COVID-19 progression》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2021-03-30
    • The spatial landscape of lung pathology during COVID-19 progression André F. Rendeiro, Hiranmayi Ravichandran, Yaron Bram, Vasuretha Chandar, Junbum Kim, Cem Meydan, Jiwoon Park, Jonathan Foox, Tyler Hether, Sarah Warren, Youngmi Kim, Jason Reeves, Steven Salvatore, Christopher E. Mason, Eric C. Swanson, Alain C. Borczuk, Olivier Elemento & Robert E. Schwartz Nature (2021) Abstract Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19)1–8. However, thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking. We use high parameter imaging mass cytometry9 targeting the expression of 36 proteins, to investigate at single cell resolution, the cellular composition and spatial architecture of human acute lung injury including SARS-CoV-2. This spatially resolved, single-cell data unravels the disordered structure of the infected and injured lung alongside the distribution of extensive immune infiltration. Neutrophil and macrophage infiltration are hallmarks of bacterial pneumonia and COVID-19, respectively. We provide evidence that SARS-CoV-2 infects predominantly alveolar epithelial cells and induces a localized hyper-inflammatory cell state associated with lung damage. By leveraging the temporal range of COVID-19 severe fatal disease in relation to the time of symptom onset, we observe increased macrophage extravasation, mesenchymal cells, and fibroblasts abundance concomitant with increased proximity between these cell types as the disease progresses, possibly as an attempt to repair the damaged lung tissue. This spatially resolved single-cell data allowed us to develop a biologically interpretable landscape of lung pathology from a structural, immunological and clinical standpoint. This spatial single-cell landscape enabled the pathophysiological characterization of the human lung from its macroscopic presentation to the single-cell, providing an important basis for the understanding of COVID-19, and lung pathology in general.
    145浏览量
    原文链接

  • 《Nature，12月24日，Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2021-02-01
    • Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19 Hong-Yi Zheng, Min Xu, Cui-Xian Yang, Ren-Rong Tian, Mi Zhang, Jian-Jian Li, Xi-Cheng Wang, Zhao-Li Ding, Gui-Mei Li, Xiao-Lu Li, Yu-Qi He, Xing-Qi Dong, Yong-Gang Yao & Yong-Tang Zheng Signal Transduction and Targeted Therapy volume 5, Article number: 294 (2020) Abstract Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. After analyzing the regulatory networks of differentially expressed messenger RNAs (mRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) between the different clinical stages, we found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features. These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease.
    38浏览量
    原文链接