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《Nature，4月6日，Fighting COVID-19 exhausts T cells》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-04-07

  • Fighting COVID-19 exhausts T cells

    Chang Moon

    Nature Reviews Immunology (2020)

    Lymphopenia is seen in severe cases of COVID-19, but the functional state of T cells in these patients is not known. Based on the retrospective study of 522 patients with COVID-19 and 40 healthy controls from Wuhan, China, this preprint study found that the age-dependent and clinical severity-dependent reduction in T cell numbers inversely correlates with serum levels of TNF, IL-6 and IL-10. The expression of T cell exhaustion markers (PD1 and TIM3) was assessed in peripheral blood cells from 14 patients with COVID-19 and 3 controls. CD8+ T cells from patients in intensive care units (ICUs) showed increased expression of PD1 compared with patients not in ICUs and healthy controls.

  • 原文来源：https://www.nature.com/articles/s41577-020-0304-7
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