登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《BioRxiv，3月20日，Scientometric Trends for Coronaviruses and Other Emerging Viral Infections》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-23

  • Scientometric Trends for Coronaviruses and Other Emerging Viral Infections

    Dima Kagan, Jacob Moran-Gilad, Michael Fire

    doi: https://doi.org/10.1101/2020.03.17.995795

    Abstract

    COVID-19 is the most rapidly expanding coronavirus outbreak in the past two decades. To provide a swift response to a novel outbreak, prior knowledge from similar outbreaks is essential. Here, we study the volume of research conducted on previous coronavirus outbreaks, specifically SARS and MERS, relative to other infectious diseases by analyzing over 45 million papers from the last 20 years. Our results demonstrate that previous coronavirus outbreaks have been understudied compared to other viruses.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.biorxiv.org/content/10.1101/2020.03.17.995795v1
10浏览量
原文链接
相关报告

  • 《3月20日_本·古里安大学研究称应采取措施鼓励COVID-19等相关领域的持续研究》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-23
    • 1.时间：2020年3月20日 2.机构或团队：本·古里安大学 3.事件概要： 以色列本·古里安大学于2020年3月20日在bioRxiv上发表题为“Scientometric Trends for Coronaviruses and Other Emerging Viral Infections”的文章，通过分析过去20年中超过4,500万篇论文，研究了与以前暴发的冠状病毒（尤其是SARS和MERS）相关的研究论文数量。文章指出，其结果表明，与其他病毒相比，以前暴发的冠状病毒相关研究不足；疫情爆发后，新发传染病的研究量非常高，并且随着疾病的遏制而急剧下降，这会导致在新型冠状病毒的管理和预防方面研究不足和投入有限。作者认为，应采取措施鼓励COVID-19等相关领域的持续研究。 4.附件： 原文链接：https://www.biorxiv.org/content/10.1101/2020.03.17.995795v1
    14浏览量
    原文链接

  • 《BioRxiv，3月2日，Kallikrein 13: a new player in coronaviral infections.》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-03
    • Kallikrein 13: a new player in coronaviral infections. Aleksandra Milewska, Katherine Falkowski, Magdalena Kalinska, Ewa Bielecka, Antonina Naskalska, Pawel Mak, Adam Lesner, Marek Ochman, Maciej Urlik, Jan Potempa, Tomasz Kantyka, Krzysztof Pyrc doi: https://doi.org/10.1101/2020.03.01.971499 Abstract Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but in vitro model for virus replication is lacking. Interaction between the coronaviral spike (S) protein and its receptor is the major determinant of virus tissue and host specificity, but virus entry is a complex process requiring a concerted action of multiple cellular elements. Here, we show that KLK13 is required for the infection of the human respiratory epithelium and is sufficient to mediate the entry of HCoV-HKU1 to non-permissive RD cells. We also demonstrated HCoV-HKU1 S protein cleavage by KLK13 in the S1/S2 region, proving that KLK13 is the priming enzyme for this virus. Summarizing, we show for the first time that protease distribution and specificity predetermines the tissue and cell specificity of the virus and may also regulate interspecies transmission. It is of importance that presented data may be relevant for the emerging coronaviruses, including SARS-CoV-2, and may help to understand the differences in their zoonotic potential. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    11浏览量
    原文链接