《Car Stories and Recollections - SOLD OUT》

  • 来源专题:科学技术史学科动态
  • 编译者: ihns
  • 发布时间:2016-03-24

  • This event is sold out. Join Hagley Curator of Mechanical Exhibitions and Car Show Chair John McCoy as he talks with car enthusiast Irénée du Pont. He is a car guy who still has every car he’s ever owned. And each one has many stories to tell. The first story begins on Christmas Eve 1935, two weeks shy of his sixteenth birthday, when he received his first car, a 1936 F-36 Oldsmobile. Join us for a delightful evening of stories about the cars that have carried Irénée du Pont through his life. This talk is free and open to the public. Reservations requested, reserve online or call (302) 658-2400. The lecture will be held in the Hagley Soda House. Use Hagley’s Buck Road East entrance off Route 100 in Wilmington, Delaware.

    Thursday, March 24, 2016

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  • 《Artificial Intelligence, Origin Stories, Machining Strategies, and the Wild Ride Ahead in 2024》

    • 来源专题:智能制造
    • 编译者:icad
    • 发布时间:2024-01-05
    • Published1/12/2024 Artificial Intelligence, Origin Stories, Machining Strategies, and the Wild Ride Ahead in 2024. The January 2024 issue of Modern Machine Shop contains several firsts. From new features to new topics and presentation styles, the debut issue of the year reflects not only a changing landscape of machining strategies, but also the stories behind the people who innovate them.#thesetup Brent Donaldson Editor-in-Chief, Modern Machine Shop Share. Read Next . 5 Tips for Running a Profitable Aerospace Shop. World Machine Tool Production and Consumption Modestly Down in 2022. Five Common Mistakes Shops Make with ER Collets (And How to Prevent Them). Buckle up. When I think about 2024, that thought comes to mind. There are simply too many events of global significance taking place this year to make 2024 a forgettable ride. To wit: It is estimated that 76 countries plan to hold elections this year, possibly making 2024 “the biggest election year in history.” In addition to elections taking place across the planet, NASA’s Artemis II is scheduled to take humans on a flyby of the moon. A total eclipse of the sun will be visible across much of North America. The quadrennial drama of the Summer Olympics will descend upon Paris. And those are just a few of the known events. Featured Content . Tips for Designing CNC Programs That Help Operators Zillow for Machine Tools? World Machine Tool Production and Consumption Modestly Down in 2022 Then there are the wildcards. Modern Machine Shop’s January 2024 cover. Photo Credit: Modern Machine Shop In its 96 years of existence, Modern Machine Shop has never explored artificial intelligence (AI) — a wildcard of epic scale — as our central cover topic. But given the rapid advance of machining automation that our writers focus on every day, it feels like the right time. In her feature on page 58, senior editor Julia Hider presents a fascinating interview with Mike Wearne, a CAD instructor and CNC programmer who has researched and published studies and videos about ChatGPT’s potential for programming G code. In Hider’s article, she describes the challenges of machine programming via ChatGPT through its existing interface, including the sheer volume of information ChatGPT requires to create a successful program. Without giving anything away, the money quote in Hider’s piece is this (emphasis added on the last sentence): “Anything beyond that is not doable. At least, not yet.” We also explore AI and AI-adjacent topics in two other articles this month. On page 18, Editorial Director Peter Zelinski explores AI’s potential through an examination of intelligence itself — “real” versus “artificial” — and the role humans will necessarily still play even as AI advances far beyond its current capabilities. And on page 71, Senior Associate Editor Eli Plaskett examines dynamic programming and the ability of machines to autonomously generate code — after humans program the part geometries and cutting paths. While referring to dynamic programming as “AI” is dubious at best, Eric Ostini, GF Machining’s head of business development for North America, puts it this way: “Dynamic programming enables the intermediate or beginner operator to function at the level of a skilled programmer and enables the skilled programmer to make more efficient use of their time.” Rounding out the rest of the feature contributions to this issue, on page 68, associate editor Nate Fields examines a briquette manufacturer that revamped its machining and cutting tool arsenal for faster production. In this case study, the combination of a Mazak Integrex turn-mill machine with a two-pallet changer and automated pallet-stocking system, coupled with indexable carbide tooling from Ceratizit and Mastercam’s 3D tool paths, was a game changer across several aspects of production. And on page 62, Associate Editor Evan Doran tells the story of entrepreneurs who used their lack of manufacturing experience to their greatest possible advantage, creating a business strategy that involved trusting machinists and taking a hands-off management style. The strategy allowed company leaders to take more risks and find success at a faster pace. Finally, I’m excited to announce that the January 2024 issue of Modern Machine Shop includes two brand-new feature presentations. First, we’re debuting a full-spread visual feature we’ve dubbed “The Cut Scene.” Put one way, “The Cut Scene” is a two-page photo feature accompanied by text callouts that describe an interesting production setup and machining activity. Put another, it is a visually compelling photo involving a machining production scene that’s meant to evoke a call-and-response: What is that, and how is it made? In this debut of “The Cut Scene,” we’re examining a snapshot from one step of Vektek’s production cycle for its hydraulic clamp bodies. These complex parts must be leak-free with precision fits and excellent surface finishes, and producing them at volume requires repeatable and flexible workholding to change parts quickly. To see the solution Vektek found, turn to page 56. 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If the Federal Government Is to Solve the Manufacturing Labor Shortage, it Needs to Start Here . Student-run businesses focused on technical training for the trades are taking root across the U.S. Can we — should we — leverage their regional successes into a nationwide platform?
  • 《CAR-T制造工艺的优化升级》

    • 来源专题:生物安全知识资源中心 | 领域情报网
    • 编译者:hujm
    • 发布时间:2018-05-10
    • 诺华公司的Kymriah以及吉利德公司的Yescarta是全球首批上市的CAR-T疗法,目前全球有多项CAR-T疗法正在申报中。与任何治疗一样,CAR-T疗法的主要挑战不仅在于安全性和有效性,还在于创建可行的商业供应链。CAR-T开发商不仅要克服安全性和有效性的障碍以通过监管部门审批,还须证明能够应对与制造相关的复杂性,并将这种个性化、时间敏感型的疗法应用至更广泛的患者群体。CAR-T制造工艺的优化是实现这些目标的关键环节之一。 CAR-T细胞制造是一个非常复杂的过程,制造难、成本高已经成为了行业发展的瓶颈问题。目前,吉利德和诺华公司均采用的是集中生产模式,首先在医院中提取患者的T细胞,然后将这些细胞运送至制造中心,在制造中心对T细胞进行基因工程设计,最后将设计后的T细胞运回医院回输至患者体内。然而,无论使用何种制造模式,成功的CAR-T细胞制造都依赖于端到端流程的优化能力,包括工作流程的简化、产能规划以及生产的可扩展性等等。传统的制造工艺以及传统设备已经不能满足行业发展需求,自动化、全封闭的新一代制造工艺是未来趋势。 随着CAR-T制造工业的发展,目前市场上已经有一些解决方案供CAR-T开发商选择,例如博雅控股集团旗下的CAR-TXpress™、美天旎的CliniMACS Prodigy™以及GE公司的FlexFactory™等,这些平台受到了整个行业的关注,业内人士也对它们充满了期待。 一个典型的CAR-T疗法流程主要分为分离、修饰、扩增、回输以及监控五个步骤。在新兴细胞治疗领域,高效分离目标细胞是细胞制品生产和质量控制的基础。传统制造工艺中,细胞分离分选常常采用Ficoll密度梯度分离法和磁珠分离法。据了解,在CAR-T制造工艺升级的道路上,CAR-TXpress™平台采用基于不同细胞组分的不同密度系数进行物理分离的X-LAB™系统以及全新的专利浮力分离法(BACS)来取代传统的Ficoll密度梯度分离法和磁珠分离法;以及采用X-Wash™系统取代了传统的离心细胞收集手段,以避免细胞清洗的数目和活力的损失。 5月初,国际细胞治疗协会(ISCT)2018年年会公布了创新浮力法细胞分选系统X-BACS™以及X-Wash™系统的最新性能数据,CAR-T细胞制造工艺的优化升级首次以数字形式呈现,有助于人们了解CAR-T制造工业的发展。 X-BACS™是一种基于浮力的细胞分选方法,将目标细胞从细胞混合物分离出来。该方法使用抗体特异性来分选细胞,使用CD3抗体在混合物中标记T细胞,并使用靶向标记T细胞的微泡从混合物中分离CD3+T细胞。 分别采用Ficoll-Hypaque和X-LAB™系统来分离MNC(单个核细胞),并采用BACS技术对这两份MNC进行CD3+T细胞分选。试验结果显示,Ficoll法制备的那份MNC经分离所得CD3+的回收率均值为83.5%,活率均值为96.3%,纯度均值为95.1% ,而X-LAB?系统制备的那份MNC经分离所得CD3+的回收率均值为89.0%, 活率均值为98.3%,纯度均值为97.3%。 简而言之,X-LAB™ 系统分离MNC后用BACS技术分选CD3+的效果优于Ficoll法分离MNC后用BACS技术分选CD3+。浮力法细胞分选系统X-BACS™可以分离获得高纯度(95%)T细胞群,且确保回收率高达85%,细胞存活率高达95%以上。该方法用标准实验室设备即可简单操作完成。 一直以来,细胞产品,如造血干细胞,在低于-135°C环境下进行为期数十年的冻存,皆采用冷冻保护剂二甲亚砜(DMSO)。虽然复苏后的细胞产品活率较高,但DMSO被认为是引发细胞回输不良反应的潜在原因,清洗已复苏细胞产品去除DMSO和细胞裂解物可以减轻某些移植并发症。X-Wash™系统法是一种简单快速清洗复苏后可回输细胞产品的方法,能够高效去除已复苏细胞产品中的DMSO,有核细胞回收率高于85%,且基本不会失活,整个过程耗时不超过1小时,并且这种方法采用标准实验室设备简单操作就能完成。 在试验中,根据供应商的操作说明将购买的健康成人冻存组织进行复苏,在已复苏产品中添加复苏清洗溶剂(含2.5%HSA、 5%葡萄聚糖以及20g/mL脱氧核糖核酸酶的生理盐水),再将样本转移至转移袋中(此步骤非必选)。将样本转移至X-Wash?系统一次性处理套件中。离心后,以正压去除废液,再以负压添加新溶剂。经最后一遍离心,细胞被收集至回收仓,溶于事先注入仓中的溶剂。试验结果显示,X-Wash™系统清洗所获CD45+细胞的总量和活率平均值分别为96.0%和93.7%;所获CD3+细胞的总量和活率平均值分别为96.3% 和92.4%。 对比发现,新一代制造工艺在细胞回收率、活性等性能上取得了显著的优化。目前,新一代CAR-T制造工艺诸如CAR-TXpress™平台融入了全新元素,不仅提高了细胞回收率等数据性能,还能够实现操作过程的自动化,避免了传统人工操作不可预期的可变性,降低制造成本、增加产品的一致性、提高运营效率、降低运营变量,有助于实现整个制造过程的标准化。