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《SSRN，3月10日，Dynamic Profile of RT-PCR Findings from 301 COVID-19 Patients in Wuhan, China: A Descriptive Study》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-11

  • Dynamic Profile of RT-PCR Findings from 301 COVID-19 Patients in Wuhan, China: A Descriptive Study

    27 Pages Posted: 10 Mar 2020

    Ai Tang Xiao

    Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Gastrointestinal Surgery

    Yi Xin Tong

    Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Gastrointestinal Surgery

    Abstract

    Background: With the spread of Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection, its effect on society is amplified. We aimed to describe the viral detection results across different timepoints throughout the disease course.

    Methods: A retrospective study of 301 confirmed COVID-19 patients hospitalized at Tongji Hospital in Wuhan, China, were included. Demographic characteristics of the patients were collected. Upper respiratory specimens (throat and/or nasal swabs) were obtained and analyzed by real-time RT-PCR for SARS-CoV-2 infection. Period of viral infection and the contagious stage were analyzed.

  • 原文来源：https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3548769
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    • 1.时间：2020年3月10日 2.机构或团队：华中科技大学 3.事件概要： SSRN预印平台的《柳叶刀》预印本于3月10日发表了华中科技大学的文章“Dynamic Profile of RT-PCR Findings from 301 COVID-19 Patients in Wuhan, China: A Descriptive Study”，旨在描述整个疾病过程中不同时间点的病毒检测结果。文中回顾性研究了中国武汉同济医院住院的301名COVID-19确诊患者的资料，收集了患者的人口统计学特征。获得了上呼吸道标本（咽和/或鼻拭子），并通过实时RT-PCR分析SARS-CoV-2感染情况，同时分析了病毒的感染周期和传染阶段。 文章结果显示，在301名住院的COVID-19患者中，中位年龄为58岁，男性为51.2％。症状出现与核酸检测阳性结果之间的中位时间为16天（IQR，10-23，N = 301）。症状出现与SARS-CoV-2 RT-PCR阴性结果之间的中位时间为20天（IQR，17-24; N = 216）。 ≥65岁的受感染患者的传染性持续时间更长（22天vs 19天，p = 0.015）。在70例患者中，尽管连续两次病毒检测为阴性结果，但其中30％的患者在第三次检测中显示为阳性病毒结果。使用鼻拭子的标本进行RT-PCR得到的检测结果显示出比使用咽拭子的标本具有更高的阳性率。 文章结论指出，这项对301名COVID-19患者的1113例RT-PCR测试结果的大规模调查显示，SARS-CoV-2感染患者的平均传染期为20天。 ≥65岁的患者需要更长的观察期和2个以上的阴性病毒检测结果来确认病情。 *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用。 4.附件： 原文链接：https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3548769
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