Immunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019
Lilei Yu, Yongqing Tong, Gaigai Shen, Aisi Fu, Yanqiu Lai, Xiaoya Zhou, Yuan Yuan, Yuhong Wang, Yuchen Pan, Zhiyao Yu, Yan Li, Tiangang Liu, Hong Jiang
doi: https://doi.org/10.1101/2020.03.03.20030650
Abstract
Background The outbreak of COVID-2019 is becoming a global public health emergency. Although its basic clinical features have been reported, the dynamic characteristics of immune system in COVID-2019 patients, especially those critical patients with refractory hypoxemia, are not yet well understood. We aim to describe the dynamic characteristics of immune system in 3 critical patients with refractory hypoxemia, and discuss the relationship between hypoxemia severity and immune cell levels, and the changes of gut microbes of COVID-2019 patient. Methods This is a retrospective study from 3 patients with 2019-nCoV infection admitted to Renmin Hospital of Wuhan University, a COVID-2019 designated hospital in Wuhan, from January 31 to February 6, 2020.
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