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《IJID，5月31日，Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-06-01

  • Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity

    Author links open overlay panelChang KyungKanga1Gi-ChanHanbcd1MinjiKimbcd1GwanghunKimbcdHyun MuShinfKyoung-HoSongagPyoeng GyunChoeaWan BeomParkaEu SukKimafHong BinKimafNam-JoongKimaHang-RaeKimbcdefMyoung-donOha

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    https://doi.org/10.1016/j.ijid.2020.05.106

    Abstract

    Objectives

    We hypothesized that immune response may contribute to progression of coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared cell-mediated immune (CMI) responses between severe and mild COVID-19 cases.

    Methods

    We examined peripheral blood mononuclear cells of laboratory-confirmed COVID-19 patients from their first and third weeks of illness. Severe pneumonia was defined as an oxygen saturation ≤ 93% at room air. Expressions of molecules related to T-cell activation and functions were analyzed by flow cytometry.

  • 原文来源：https://www.sciencedirect.com/science/article/pii/S1201971220304136
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    • 编译者：xuwenwhlib
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    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-06-01
    • Clinical Features and Short-term Outcomes of Elderly Patients With COVID-19 Author links open overlay panelPingLiaLuluChenaZhemingLiuaJinghuiPanaDingyiZhouaHuiWangaHongyunGongaZhenminFuaQibinSongaQianMinaShashaRuanaTangpengXuaFanChengbXiangpanLia Show more https://doi.org/10.1016/j.ijid.2020.05.107 Abstract Background The outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency. Methods 204 elderly patients (≥60 years old) diagnosed with COVID-19 in Renmin Hospital of Wuhan University from January 31st to February 20th, 2020 were included in this study. Clinical endpoint was in-hospital death.
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