《LANCET,2月8日,What to do next to control the 2019-nCoV epidemic?》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-02-07
  • What to do next to control the 2019-nCoV epidemic?

    Fu-Sheng Wang, Chao Zhang

    Published:February 08, 2020DOI:https://doi.org/10.1016/S0140-6736(20)30300-7

    The 2019 novel coronavirus (2019-nCoV) infection can lead to acute resolved or fatal pneumonia. On the basis of knowledge of other coronaviruses, the main route of human-to-human transmission of 2019-nCoV is probably through respiratory droplets. As of Feb 4, 2020, statistical data show that the outbreak constitutes an epidemic threat in China, where the exponential increase in patients has reached 20?438 confirmed cases, with 2788 (13·64%) patients in critical condition and 425 (2·08%) deaths; 23?214 additional suspected cases have also been identified so far. The most affected city, Wuhan, and related regions in Hubei province of China have reported 13?522 confirmed patients (66·16% of total cases) and 414 deaths from 2019 nCoV infection (97·41% of total deaths in China). 632 patients with confirmed infection have recovered and have been discharged from hospital. However, the downward turning point for new cases of infection has not been observed yet (figure). Notably, 159 confirmed cases have been reported in 23 other countries beyond China, including Japan, Thailand, Singapore, South Korea, Australia, the USA, Malaysia, and Germany. Because of the seriousness of this outbreak, WHO declared it a public health emergency of international concern on Jan 30, 2020, followed by the USA announcing a public health emergency on Jan 31, 2020.

  • 原文来源:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30300-7/fulltext
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  • 《LANCET,2月6日,2019-nCoV epidemic: what about pregnancies?》

    • 来源专题:COVID-19科研动态监测
    • 编译者:xuwenwhlib
    • 发布时间:2020-02-07
    • 2019-nCoV epidemic: what about pregnancies? Guillaume Favre,Léo Pomar,Didier Musso,David Baud Published:February 06, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30311-1 On Feb 3, 2020, WHO confirmed 17?238 cases of novel coronavirus (2019-nCoV) infections in China. Among them, 2296 (13%) cases were reported as severe, and 361 deaths were declared (2%).1 Members of the coronavirus family responsible for severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV) are known to be responsible for severe complications during pregnancy.2, 3 12 pregnant women were infected with SARS-CoV during the 2002–03 pandemic.2 Four (57%) of seven women in the first trimester had a miscarriage. In the second to third trimester, two (40%) of five women had fetal growth restriction, and four (80%) of five women had preterm birth (one spontaneous; three induced for maternal condition). Three (25%) women died during pregnancy. In a review of 11 pregnant women infected with MERS-CoV,3 ten (91%) presented with adverse outcomes, six (55%) neonates required admission to the intensive care unit, and three (27%) died. Two neonates were delivered prematurely for severe maternal respiratory failure. Considering that the 2019-nCoV seems to have a similar pathogenic potential as SARS-CoV and MERS-CoV,4 pregnant women are at increased risk of severe infections, there are no specific clinical signs of coronavirus infections preceding severe complications,5 coronaviruses have the potential to cause severe maternal or perinatal adverse outcomes, or both,2, 3 and the current lack of data on the consequences of a 2019-nCoV infection during pregnancy, we recommend systematic screening of any suspected 2019-nCoV infection during pregnancy. If 2019-nCoV infection during pregnancy is confirmed, extended follow-up should be recommended for mothers and their fetuses.
  • 《LANCET,2月7日,Pandemic potential of 2019-nCoV》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-02-09
    • Pandemic potential of 2019-nCoV Robin Thompson Published:February 07, 2020DOI:https://doi.org/10.1016/S1473-3099(20)30068-2 An important determinant of whether or not 2019 novel coronavirus (2019-nCoV) will ultimately cause a global pandemic is its ability to become established upon its importation to a new country. Cases of 2019-nCoV infection have so far been reported in 24 countries, yet little human-to-human transmission outside of China has occurred.