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《NEJM，5月13日，Transmission of SARS-CoV-2 in Domestic Cats》

  • 来源专题：COVID-19科研动态监测
  • 编译者： xuwenwhlib
  • 发布时间：2020-05-14

  • Transmission of SARS-CoV-2 in Domestic Cats

    May 13, 2020 DOI: 10.1056/NEJMc2013400 Metrics

    Reports of human-to-feline transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1 and of limited airborne transmission among cats2 prompted us to evaluate nasal shedding of SARS-CoV-2 from inoculated cats and the subsequent transmission of the virus by direct contact between virus-inoculated cats and cats with no previous infection with the virus. Three domestic cats were inoculated with SARS-CoV-2 on day 0. One day after inoculation, a cat with no previous SARS-CoV-2 infection was cohoused with each of the inoculated cats to assess whether transmission of the virus by direct contact would occur between the cats in each of the three pairs (Table S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org). Nasal and rectal swab specimens were obtained daily and immediately assessed for infectious virus on VeroE6/TMPRSS2 cells.3

  • 原文来源：https://www.nejm.org/doi/full/10.1056/NEJMc2013400?query=featured_home
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  • 《bioRxiv，5月29日，Pathogenesis, transmission and response to re-exposure of SARS-CoV-2 in domestic cats》
    • 来源专题：COVID-19科研动态监测
    • 编译者：xuwenwhlib
    • 发布时间：2020-06-02
    • Pathogenesis, transmission and response to re-exposure of SARS-CoV-2 in domestic cats Angela M. Bosco-Lauth, Airn E. Hartwig, Stephanie M. Porter, Paul W. Gordy, Mary Nehring, Alex D. Byas, Sue VandeWoude, Izabela K. Ragan, Rachel M. Maison, Richard A. Bowen doi: https://doi.org/10.1101/2020.05.28.120998 Abstract The pandemic caused by SARS-CoV-2 has reached nearly every country in the world with extraordinary person-to-person transmission. The most likely original source of the virus was spillover from an animal reservoir and subsequent adaptation to humans sometime during the winter of 2019 in Wuhan Province, China. Because of its genetic similarity to SARS-CoV-1, it is likely that this novel virus has a similar host range and receptor specificity. Due to concern for human-pet transmission, we investigated the susceptibility of domestic cats and dogs to infection and potential for infected cats to transmit to naïve cats. We report that cats are highly susceptible to subclinical infection, with a prolonged period of oral and nasal viral shedding that is not accompanied by clinical signs, and are capable of direct contact transmission to other cats. These studies confirm that cats are susceptible to productive SARS-CoV-2 infection, but are unlikely to develop clinical disease. Further, we document that cats develop a robust neutralizing antibody response that prevented re-infection to a second viral challenge. Conversely, we found that dogs do not shed virus following infection, but do mount an anti-viral neutralizing antibody response. There is currently no evidence that cats or dogs play a significant role in human exposure; however, reverse zoonosis is possible if infected owners expose their domestic pets during acute infection. Resistance to re-exposure holds promise that a vaccine strategy may protect cats, and by extension humans, to disease susceptibility.
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  • 《NEJM，5月28日，Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-05-29
    • Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility List of authors. Melissa M. Arons, R.N., Kelly M. Hatfield, M.S.P.H., Sujan C. Reddy, M.D., Anne Kimball, M.D., Allison James, Ph.D., Jesica R. Jacobs, Ph.D., Joanne Taylor, Ph.D., Kevin Spicer, M.D., Ana C. Bardossy, M.D., Lisa P. Oakley, Ph.D., Sukarma Tanwar, M.Med., Jonathan W. Dyal, M.D., et al., for the Public Health–Seattle and King County and CDC COVID-19 Investigation Team* Abstract BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can spread rapidly within skilled nursing facilities. After identification of a case of Covid-19 in a skilled nursing facility, we assessed transmission and evaluated the adequacy of symptom-based screening to identify infections in residents. METHODS We conducted two serial point-prevalence surveys, 1 week apart, in which assenting residents of the facility underwent nasopharyngeal and oropharyngeal testing for SARS-CoV-2, including real-time reverse-transcriptase polymerase chain reaction (rRT-PCR), viral culture, and sequencing. Symptoms that had been present during the preceding 14 days were recorded. Asymptomatic residents who tested positive were reassessed 7 days later. Residents with SARS-CoV-2 infection were categorized as symptomatic with typical symptoms (fever, cough, or shortness of breath), symptomatic with only atypical symptoms, presymptomatic, or asymptomatic.
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