登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《Science，3月27日，Underpromise, overdeliver》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-28

  • Underpromise, overdeliver

    H. Holden Thorp

    See all authors and affiliations

    Science 27 Mar 2020:

    Vol. 367, Issue 6485, pp. 1405

    DOI: 10.1126/science.abb8492

    The majority of crises that most of us have lived through have not looked to science for immediate answers. In many cases, much of the scientific analysis came after the fact—the effects of climate change on extreme weather events; the causes of nuclear accidents; and the virology of outbreaks that were contained such as severe acute respiratory syndrome (SARS) in 2002–2003 or Middle East respiratory syndrome (MERS) in 2012. Now, science is being asked to provide a rapid solution to a problem that is not completely described.

  • 原文来源：https://science.sciencemag.org/content/367/6485/1405
10浏览量
原文链接
相关报告

  • 《Science，3月27日，Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-27
    • Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 Renhong Yan1,2, Yuanyuan Zhang1,2,*, Yaning Li3,*, Lu Xia1,2, Yingying Guo1,2, Qiang Zhou1,2,† See all authors and affiliations Science 27 Mar 2020: Vol. 367, Issue 6485, pp. 1444-1448 DOI: 10.1126/science.abb2762 Abstract Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing the serious coronavirus disease 2019 (COVID-19) epidemic. Here, we present cryo–electron microscopy structures of full-length human ACE2 in the presence of the neutral amino acid transporter B0AT1 with or without the receptor binding domain (RBD) of the surface spike glycoprotein (S protein) of SARS-CoV-2, both at an overall resolution of 2.9 angstroms, with a local resolution of 3.5 angstroms at the ACE2-RBD interface. The ACE2-B0AT1 complex is assembled as a dimer of heterodimers, with the collectrin-like domain of ACE2 mediating homodimerization. The RBD is recognized by the extracellular peptidase domain of ACE2 mainly through polar residues. These findings provide important insights into the molecular basis for coronavirus recognition and infection.
    133浏览量
    原文链接

  • 《Science，3月27日，Travel restrictions violate international law》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-27
    • Travel restrictions violate international law Benjamin Mason Meier1,*, Roojin Habibi2, Y. Tony Yang3 See all authors and affiliations Science 27 Mar 2020: Vol. 367, Issue 6485, pp. 1436 DOI: 10.1126/science.abb6950 From China's lockdown of the city of Wuhan (1) to U.S. restrictions on travelers from Europe (2) to border closures across a widening range of countries (3), governments are increasingly seeking to limit freedom of movement in response to the coronavirus disease 2019 (COVID-19). These travel restrictions have slowed, but not halted, the spread of the pandemic (“The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak,” M. Chinazzi et al., Research Articles, published online 6 March, p. eaba9757). However, the necessity and benefits of this public health response are outweighed by its violation of international law.
    26浏览量
    原文链接