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《MedRxiv，3月16日，Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-17

  • Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China

    Yaling Shi, Mingkai Tan, Xing Chen, Yanxia Liu, Jide Huang, Jingyi Ou, Xilong Deng

    doi: https://doi.org/10.1101/2020.03.12.20034736

    Abstract

    Coronavirus disease 2019 (COVID-19) is a respiratory disorder caused by the highly contagious SARS-CoV-2. The immunopathological characteristics of COVID-19 patients, either systemic or local, have not been thoroughly studied. In the present study, we analyzed both the changes in the cellularity of various immune cell types as well as cytokines important for immune reactions and inflammation. Our data indicate that patients with severe COVID-19 exhibited an overall decline of lymphocytes including CD4+ and CD8+ T cells, B cells, and NK cells. The number of immunosuppressive regulatory T cells was moderately increased in patients with mild COVID-19. IL-2, IL-6, and IL-10 were remarkably up-regulated in patients with severe COVID-19.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.medrxiv.org/content/10.1101/2020.03.12.20034736v1
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