登录
 机构网站
  1. 首页
  2. 情报产品
  3. 快讯详情

《MedRixv，2月29日，Sex differences in clinical findings among patients with coronavirus disease 2019 (COVID-19) and severe condition》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-03-01

  • Sex differences in clinical findings among patients with coronavirus disease 2019 (COVID-19) and severe condition

    Jing Li, Yinghua Zhang, Fang Wang, Bing Liu, Hui Li, Guodong Tang, Zhigang Chang, Aihua Liu, Chunyi Fu, Jing Gao, Jing Li

    doi: https://doi.org/10.1101/2020.02.27.20027524

    Abstract

    Objective: To compare the sex differences in the clinical findings among patients with severe coronavirus disease 2019 (COVID-19). Methods: We retrospectively collected data of 47 patients diagnosed as severe type of COVID-19 from February 8 to 22, 2020, including demographics, illness history, physical examination, laboratory test, management, and compared differences between men and women.

    *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.

  • 原文来源：https://www.medrxiv.org/content/10.1101/2020.02.27.20027524v1
28浏览量
原文链接
相关报告

  • 《MedRixv，2月29日，Hypokalemia and Clinical Implications in Patients with Coronavirus Disease 2019 (COVID-19)》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-03-01
    • Hypokalemia and Clinical Implications in Patients with Coronavirus Disease 2019 (COVID-19) dong chen Jr., Xiaokuni Li, qifa song Sr., Chenchan Hu Jr., Feifei Su, Jianyi Dai doi: https://doi.org/10.1101/2020.02.27.20028530 Abstract BACKGROUND: SARS-CoV-2 has caused a series of COVID-19 globally. SARS-CoV-2 binds angiotensin I converting enzyme 2 (ACE2) of renin-angiotensin system (RAS) and causes prevalent hypokalemia METHODS: The patients with COVID-19 were classified into severe hypokalemia, hypokalemia, and normokalemia group. The study aimed to determine the relationship between hypokalemia and clinical features, the underlying causes and clinical implications of hypokalemia. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    23浏览量
    原文链接

  • 《MedRixv，2月23日，The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province》
    • 来源专题：COVID-19科研动态监测
    • 编译者：zhangmin
    • 发布时间：2020-02-24
    • The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province Jinwei Ai, Junwen Chen, Yong Wang, Xiaoyun Liu, Wufeng Fan, Gaojing Qu, Meiling Zhang, Shengduo Polo Pei, Bowen Tang, Shuai Yuan, Yang Li, Lisha Wang, Guoxin Huang, Bin Pei doi: https://doi.org/10.1101/2020.02.19.20025023 Abstract Summary Objective To describe the epidemiological and clinical characteristics of the Coronavirus Disease 2019 (COVID-19) hospitalized patients and to offer suggestions to the urgent needs of COVID-19 prevention, diagnosis and treatment. Methods We included 102 confirmed COVID-19 cases hospitalized in Xiangyang No.1 peoples hospital, Hubei, China until Feb 9th, 2020. Demographic data, laboratory findings and chest computed tomographic (CT) images were obtained and analyzed. Findings All cases were confirmed by real-time RT-PCR, including 52 males and 50 females with a mean age of 50.38 years (SD 16.86). Incubation time ranged from one to twenty days with a mean period of 8.09 days (SD 4.99). Fever (86[84.3%] of 102 patients), cough (58[57%]), fatigue (28[27%]), shortness of breath (24[23%]), diarrhea (15[15%]), expectoration (13[12%]), inappetence (11[10%]) were common clinical manifestations. We observed a decreased blood leukocyte count and lymphopenia in 21 (20.6%) and 56 (54.9%) patients, respectively. There were 66 (68%) of 97 patients with elevated C-reactive protein levels and 49 (57.6%) of 85 with increased erythrocytes sedimentation rate. Higher levels of procalcitonin and ferritin were observed in 19 (25.3%) of 75 and 12 (92.3%) of 13 patients, respectively. Eight patients were admitted to intensive care unit (ICU), six developed respiratory failure, three had multiple organ failure and three died. The cumulative positivity rate over three rounds of real-time RT-PCR was 96%. One-hundred patients were found with typical radiological abnormalities in two rounds of chest CT scans, indicating a 98% consistency with real-time RT-PCR results. Interpretation Most COVID-19 patients in Xiangyang were secondary cases without sex difference, and the rate of severe cases and death was low. Middle-to-old-age individuals were more susceptible to the virus infection and the subsequent development of severe/fatal consequences. The average incubation period was longer among our patients. We recommend prolonging the quarantine period to three weeks. Three times real-time RT-PCR plus two times CT scans is a practical clinical diagnosis strategy at present and should be used to increase the accuracy of diagnosis, thereby controlling the source of infection more effectively. *注，本文为预印本论文手稿，是未经同行评审的初步报告，其观点仅供科研同行交流，并不是结论性内容，请使用者谨慎使用.
    38浏览量
    原文链接