《MedRixv,2月25日,Epidemiological and clinical characteristics of SARS-CoV-2 and SARS-CoV: a system review》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-02-26
  • Epidemiological and clinical characteristics of SARS-CoV-2 and SARS-CoV: a system review

    mao yaqian, Wei Lin, Junping Wen, Gang Chen

    doi: https://doi.org/10.1101/2020.02.20.20025601

    Abstract

    Background: In this article, we summarized the early epidemiologic and clinical characteristics of SARS and COVID-19 in different countries. Aim to provide recommendations for the understanding and prevention of COVID-19. Methods: By searching pubmed, we analyzed and compared the typical cases of SARS and COVID-19 in different countries in the early stage of the outbreak. Clinical records, laboratory results, imageological diagnosis and pathologic condition were retrospectively reviewed for these cases. This paper adopts the method of descriptive statistics and tables and graphs.

    *注,本文为预印本论文手稿,是未经同行评审的初步报告,其观点仅供科研同行交流,并不是结论性内容,请使用者谨慎使用.

  • 原文来源:https://www.medrxiv.org/content/10.1101/2020.02.20.20025601v1
相关报告
  • 《SARS-CoV-2和SARS-CoV的流行病学和临床特征》

    • 来源专题:生物安全知识资源中心 | 领域情报网
    • 编译者:hujm
    • 发布时间:2020-02-29
    • 福建省立医院于2020年2月25日在medRxiv上发表题为“Epidemiological and clinical characteristics of SARS-CoV-2 and SARS-CoV: a system review”的文章。 研究人员通过搜索pubmed,分析和比较了疫情爆发初期不同国家SARS和COVID-19的典型病例。回顾性分析这些病例的临床记录、实验室检查结果、影像学诊断和病理状况。结果显示,有6篇SARS相关文章(N=337名参与者)和12篇COVID-19相关文章(N=50,096名参与者)符合此系统分析的条件。发热、咳嗽和不适/疲劳是SARS和COVID-19中最常见的症状。但总体而言,COVID-19的临床症状和特征并不明显。与SARS相比,COVID-19的传播方式更加多样,人传人、无症状感染者以及可能的粪口传播都为其大规模传播创造了条件。 SARS和COVID-19的死亡率分别为7.7%和2.2%,但医护人员COVID-19的总体感染率(3.9%)低于SARS(40.0%)。研究人员还总结了有关COVID-19病理的最新报道,发现COVID-19的病理特征与SARS非常相似,后者表现为急性呼吸窘迫综合征(ARDS)。研究人员指出,中国SARS和COVID-19的流行病学和临床特征非常相似,但也有差异。COVID-19的传播途径更加多样且更具传染性,因此医护人员和患者对疾病的早期识别非常重要。必须采取积极有效的隔离措施,以应对疑似病例和近距离接触者。
  • 《Nature,5月5日,Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-05-06
    • Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis Huan Li, Chongxiang Chen, Fang Hu, Jiaojiao Wang, Qingyu Zhao, Robert Peter Gale & Yang Liang Leukemia (2020) Abstract We performed a meta-analysis to determine safety and efficacy of corticosteroids in SARS-CoV-2, SARS-CoV, and MERS-CoV infections. We searched PubMed, Web of Science, Medline, WanFang Chinese database, and ZhiWang Chinese database using Boolean operators and search terms covering SARS-CoV-2, SARS-CoV, OR MERS-CoV AND corticosteroids to find appropriate studies. Review Manager 5.3 was used to analyze results of meta-analysis. Observational studies were analyzed for quality using the modified Newcastle–Ottawa scale and randomized clinical trials, using the Jadad scale. Subjects were divided into those with severe-only and other (severe and not severe) cohorts based on published criteria. Efficacy endpoints studied included mortality, hospitalization duration, rates of intensive care unit (ICU) admission, use of mechanical ventilation, and a composite endpoint (death, ICU admission, or mechanical ventilation).