《Nature,3月9日,How monkeys, mice and ferrets are helping scientists to fight coronavirus》

  • 来源专题:COVID-19科研动态监测
  • 编译者: zhangmin
  • 发布时间:2020-03-10
  • As coronavirus marches around the globe, a sleepy town on the rugged Maine coast has become an unlikely nucleus in researchers’ efforts to combat the disease, known as COVID-19. The Jackson Laboratory, a mouse-breeding facility in Bar Harbor, is rushing to produce stocks of a transgenic mouse that scientists hope will help them to understand the virus.

  • 原文来源:https://www.nature.com/articles/d41586-020-00698-x
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  • 《Nature,3月24日,How to help the free market fight coronavirus》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-25
    • About five weeks after cases of COVID-19 began to appear, scientists based in Shanghai, China, deposited the first 3D structure of a crucial protein from the virus causing the disease into the Protein Data Bank (PDB), an open-access repository for data on biological structures. As happened with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) — both also caused by coronaviruses — scientists are sharing information in ways not typical for a competitive, commercial field. Knowing the shapes of proteins from the virus that causes COVID-19 could accelerate the discovery of drugs and vaccines. But that will not happen if other barriers — financial, regulatory or legal — get in the way. Lowering them is essential to defending against COVID-19 and preparing for the inevitable future outbreaks.
  • 《3月9日_动物模型在抗击冠状病毒中的作用》

    • 来源专题:COVID-19科研动态监测
    • 编译者:zhangmin
    • 发布时间:2020-03-10
    • 1.时间:2020年3月9日 2.信息来源:Nature 3.事件概要: Nature发表名为“How monkeys, mice and ferrets are helping scientists to fight coronavirus”新闻稿,旨在阐述动物模型在抗击冠状病毒中的作用。文章称多个动物模型机构正争分夺秒的生产试验动物,以助力科研人员研究病毒以及药物和疫苗研发。 中国科研小组最先证明,猕猴和小鼠体内含有ACE2基因,可用于COVID-19的研究;澳大利亚吉朗动物健康实验室称雪貂易感染SARS-CoV-2,又由于雪貂的肺部生理结构与人类相似,因此可用于研究COVID-19在人体内的传播方式;中国科学院武汉病毒研究所发现,猕猴会出现与轻度患有COVID-19人群相似的症状。 此外,在等待人源化hACE2小鼠的同时,多个实验室正在开展实验:密苏里州圣路易斯华盛顿大学病毒免疫学家Michael Diamond期望利用CRISPR基因编辑技术来鉴定小鼠易感和抗感染基因;Diamond团队也正在开发其他小鼠模型;中国一研究小组已拥有人源化hACE2 小鼠,经冠状病毒感染后,出现轻度的症状;研究人员还检测到了被感染小鼠的免疫反应;同时,研究团队发现了几种药物可减缓病毒的复制。 4.附件: 原文链接:https://www.nature.com/articles/d41586-020-00698-x