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《Science，11月20日，Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms》

  • 来源专题：COVID-19科研动态监测
  • 编译者： zhangmin
  • 发布时间：2020-12-22

  • Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
    View ORCID ProfileM. Alejandra Tortorici1,2,*, View ORCID ProfileMartina Beltramello3,*, Florian A. Lempp4, Dora Pinto3, View ORCID ProfileHa V. Dang1, View ORCID ProfileLaura E. Rosen...

    Science  20 Nov 2020:
    Vol. 370, Issue 6519, pp. 950-957
    DOI: 10.1126/science.abe3354

    Abstract
    Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 September 2020. We report the isolation and characterization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-CoV-2 challenge. Cryo–electron microscopy structures show that S2E12 and S2M11 competitively block angiotensin-converting enzyme 2 (ACE2) attachment and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epitope spanning two adjacent receptor-binding domains. Antibody cocktails that include S2M11, S2E12, or the previously identified S309 antibody broadly neutralize a panel of circulating SARS-CoV-2 isolates and activate effector functions. Our results pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants.

  • 原文来源：https://science.sciencemag.org/content/370/6519/950
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